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Post by bannanny on Jul 8, 2009 1:25:32 GMT -5
March 27th, 2009 lifeafterlymedisease.com/Researchers at UT Southwestern Medical Center have identified a protein that may help give Lyme disease its bite. The findings suggest that the bacterial protein, which aids in transporting the metal manganese, is essential for the bacterium that causes Lyme disease to become virulent. "We believe our findings provide a foundation for further defining metal homeostasis in this human pathogen and may lead to new strategies for thwarting Lyme disease," said Dr. Michael Norgard , chairman of microbiology at UT Southwestern and senior author of a study now online and in an upcoming issue of the Proceedings of the National Academy of Sciences. Lyme disease, discovered in 1977, is the most prevalent tick-borne infection in the U.S. Borrelia burgdorfei , the bacterium that causes Lyme disease, lives in infected mammals and in the midgut of ticks. When an infected tick bites an animal or a human, the bacteria are transmitted to the new host. Infection causes fever, malaise, fatigue, headache, muscle and joint aches, and a characteristic "bull’s-eye" rash that surrounds the site of infection. To establish infection, however, the bacterium also must acquire a number of essential nutrients, including metals like manganese from its mammalian and tick hosts. Until now, no metal transporter responsible for this acquisition had been identified in this bacterium. In the current study, microbiologists examined whether bacteria genetically engineered to lack this manganese transporter, called BmtA, transmitted Lyme disease to ticks and mice. The bacterium lacking the transporter, Dr. Norgard said, grows a bit more slowly in the test tube but is not dramatically different from the normal version. "When you try to grow it in a mouse, however, it can’t grow," he said. "The fact that the bacterium without this particular manganese transporter can’t grow in a mouse raises important questions about what aspects of physiology and metabolism contribute to the pathogenicity of the organism." Lead author Dr. Zhiming Ouyang, postdoctoral researcher in microbiology at UT Southwestern, said another newly discovered characteristic about the bacterium that causes Lyme disease is that it doesn’t seem to require iron to function, something most other pathogens need to survive. "Out of the thousands of bacteria known, the Lyme disease agent and only one or two other bacterial species do not require iron for growth," Dr. Ouyang said. "That raises the question as to what other metal co-factors the Lyme disease bacterium depends on to carry out the work that iron does for all these other biological systems. Our research suggests that manganese is a really important one." The next step is to understand the exact mechanism of how manganese functions in the organism. "I really think that there’s also something to the notion that manganese may regulate the expression of other virulence factors," Dr. Norgard said. "It could be that manganese has more of an indirect effect, but more research is needed to determine what must happen for Borrelia burgdorfei to become virulent." Researchers from Indiana University School of Medicine collaborated on the study. The research was funded by the National Institute of Allergy and Infectious Diseases. www.utsouthwestern.edu/I googled BmtA and only got results for British Motor Trade Assoc. and Mass Transit Assoc., etc. etc. Didn't see anything that even came close to a genetically engineered manganese transporter called BmtA. I even typed it in the upper case, lower case way it's typed in the article. I dunno, I just have this feeling we need to look into this. I've been bringin it up again that I've always thought something could've been added to the Lyme cocktail to produce morgellons. Especially since there seems to be a connection between the two. Lyme + a little extra GM spice = morgellons?? Could also be they actually just identified the unknown protein in morgellons here too, not Lyme. hugs ~~ bannanny
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Post by toni on Jul 8, 2009 7:26:42 GMT -5
That's very interesting.
I'll check up on that Bannanny - the Manganese which is sounding very familar (read about it, but it's been awhile)
(I've wondered also what you said)
Lyme + GM = Morgs
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Post by toni on Jul 8, 2009 7:34:58 GMT -5
Here's something about EDTA and metal chelation which has been talked about. (this link does seem very familar too, I have posted this article before) BmtA mutants were sensitive to the chelating actions of EDTA, suggesting a role for BmtA in metal utilization. Intracellular accumulation of manganese (Mn) was substantially diminished in the bmtA mutant, indicating that BmtA was operative in Mn uptake. Given that BmtA lacks homology to any known Mn transporter, we postulate that BmtA is part of a novel mechanism for Mn acquisition by a bacterial pathogen. BmtA also was essential to the infectious life cycle of Bb in ticks and mammals, thereby qualifying BmtA as a new borrelial virulence factor. www.ncbi.nlm.nih.gov/pubmed/19218460
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Post by toni on Jul 8, 2009 7:38:59 GMT -5
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Post by toni on Jul 8, 2009 8:07:49 GMT -5
Natural chelators: Chelation: The process of using chelating agents, i.e., special chemical compounds, to bind or inactivate molecules, such as poisonous heavy metals, and "chelate", or remove, them from the body. Chelation is an important aspect of natural detoxification of the body. Oral chelators like EDTA, Niacin, B-Vitamins, Folic Acid, Cilantro Extract, Ginkgo Biloba Extract, Rhodiola Rosea Extract, Alpha Lipoic Acid, Malic Acid, Vitamin C, Chlorella, Garlic and other herbs can improve your health and are good for prevention of disease. www.ripplecreek.com/glossary.html
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Post by bannanny on Jul 10, 2009 2:14:03 GMT -5
Hey tonio, what I meant when I said, [glow=red,2,300]Lyme + GM = morgs [/glow] is this... It could be since so many of us morgies also have Lyme, morgellons actually could've been created when someone decided to mix some additional ingredients into the Lyme bacteria. They mutate bacterias and viruses and whatever they feel inclined to all the time. So why couldn't it be that's how morgellons came to be? It's just something that came to mind one day. But when I read the article above, I thought this BmtA could actually be one of the things that were mixed into the original Lyme cocktail... therefore altering it and creating what we know as morgellons. Especially since they're just now seeing it. Think about it with what they're saying here too... [glow=red,2,300]we postulate that[/glow] BmtA is part of a novel mechanism [glow=red,2,300]for Mn acquisition by a bacterial pathogen. [/glow] [glow=red,2,300]BmtA also was essential to the infectious life cycle of Bb in ticks and mammals,[/glow] thereby qualifying BmtA as a new borrelial virulence factor.Then when I saw these pics at the link above, I really started to think it's a possibility. I forgot to post them last night tho... sorry about that. But here's the same chains you showed in freaky and rhorns matching pictures right here in living color. They're Borrelia burgdorfei... so yeah, I figure there's definitely gotta be a Lyme/morgellons connection now... It's also been said that us morgies are showing heavy metals in us too... some have had good results with chelation therapy. I'd be curious to know just what some manganese would do to your lesions ruth. If you can find it, you never know what it might tell us ya know? I've got my fingers and toes crossed for ya tho ruth... and you're in my prayers too. hugs ~~ bannanny
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Post by toni on Jul 10, 2009 8:37:40 GMT -5
Bannanny,
Yes, Morgellons sure could be (a combo of both), and I did understand what you meant.
Those pics of the chains, ( I don't believe though we can see borrelia) in a macroscopic view.
The borrelia bacteria is MUCH smaller than our scopes will allow.
Rhorn and Freaky said their "chains" are very macro, so imho, I believe someone who took those pictures (the Lymephotos 2002) didn't understand that part.
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Post by beckybailey on Jul 10, 2009 10:02:03 GMT -5
bannanny, you know me, I just wrote the good doctor Michael Norgard an email. Manganese is one of the things they found in my well at above average levels. Manganese poisoning is manganism. They also found bromide which causes bromism. Both have mental symptoms and skin symptoms. www.manganismfyi.com/manganism_glossary.htmlI was tweezing a new "splinter" feeling area and touched the tweezers to shipping tape each time, then looked under the microscope and once again found what looks like a proturan. Was it biting me? There was a tiny area of skin missing but I didn't tweeze my skin. I read about their cousin, the springtail, irritating skin if their bellies were rubbed on skin. I believe bannanny found one of these too. tinyurl.com/5t6lwfwill the mystery ever end?
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Post by Jill on Jul 10, 2009 10:27:32 GMT -5
I posted about Mark Purdeys' research as relates to Manganese a year or so ago. The Manganese produces the 'abnormal' prion- in Mad Cow/Alzheimers- so I would see where they could relate this to Lyme disease. www.markpurdey.com/Scientific support for empirical observations Purdey then found that his work connected very well with the work of Dr. David Brown of Cambridge University. Dr. Brown had demonstrated that normal, healthy prion protein bonds to copper in the normal, healthy brain and nervous system. Remember, this prion protein is a normal constituent of a normal brain; it is abnormal or deformed prion proteins that are associated with spongiform encephelopathy disease.Is it the abnormal prion that causes the disease or is it some unhealthy factor in the environment that causes the prion to become deformed and abnormal and this leads to the disease? Purdey published a paper proposing that: Manganese could, in the presence of copper deficiency in the animal or human, substitute for copper in the prion protein, thus producing the abnormal prion found in the brains of spongiform encephelopathy disease victims.
This was a hypothesis based on his field work in the areas where clusters of mad cow and CJD were occurring and where, he observed, all these areas had unusually low levels of copper in the soil and unusually high levels of manganese in either the soil or the atmosphere. Purdey reports that, “David Brown ran the necessary cell-culture experiments, in which he introduced manganese into copper-depleted prion protein cell cultures.” Behold the mutated prion www.markpurdey.com/articles_educatingrida_5.htmExcerpt: It seemed that the basic cornerstone of the environmental theory was beginning to establish itself, and an overall picture of the pathogenesis of this disease was panning out. That a high manganese/low copper imbalance somehow compromised the brain’s ability to deal with acute shock bursts of sound and light – the other common characteristics of TSE ecosystems.
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Post by Jill on Jul 10, 2009 10:33:59 GMT -5
www.ourcivilisation.com/madcow/madcow.htmAn Explanation Of Mad Cow Disease by Mark Purdey Fair use Excerpt: Hard evidence has been amassed so far which indicates that vCJD and BSE could both result from separate exposure of cattle and humans to the same set of toxic environmental factors—excess manganese and oxidizing agents—and not from the ingestion of beef by humans and animal by-products by cows. If this hypothesis continues to accumulate corroborative evidence, a radical upheaval of the status quo mindset can be expected.end excerpt Excerpt: Prion protein is expressed in other tissues of the body which are also interconnected to the network that conducts electromagnetic energy, for instance in the spleen, lymphatic system, glial cells and nerve-growth-factor-mediated stem cells that proliferate during the growth and repair of neurons.In this respect, the suggestion of an electro-conducting function of the copper prion protein may turn out to give further scientific substance to the existence of the electromagnetic meridians recognized by Chinese medicine, where the healthy copper prion performs a regulatory role in maintaining the electro-homeostasis along these meridians. The hypothesis was falling into place: copper prions as the conductors and manganese prions as the blockers of electromagnetic energy flow. The fact that copper is used in wires that carry electric currents, whereas manganese is used in batteries and light bulb filaments that store electrical energy, helps explain the underlying cause of prion diseases: healthy copper prions conduct the vital electro-energy of sunlight along the circadian pathways that innervate deep into the brain—in order to maintain the balanced cycles of sleep, sex and behavior whilst aberrant manganese-contaminated prions blockade and store up that incoming UV energy to an explosive flash point—to a level that detonates off neuropathogenic cluster bombs of free radical chain reactions along the circadian pathways.With an overabundance of manganese prions and loss of copper prions, the oxidative impact of UV energy received at the retina can no longer be quenched. Consequently, the energy flow of UV piles up, finding itself misappropriated into converting the accumulated store of innocuous manganese 2+ ( antioxidant ) into its lethal manganese 3+ or 4+ form (pro-oxidant). So any accumulations of abnormal manganese prion protein in the retina finds itself transformed from a safe to a lethal form. In this respect eco-oxidants such as UV serve to unleash a kind of "Jekyll and Hyde" effect in the manganese-contaminated, copper-depleted mammal, which, in turn, kicks off a whole chain reaction of free radical assault on the central nervous system—ultimately resulting in a neurodegenerative meltdown that leads to spongiform disease.
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Post by toni on Jul 10, 2009 11:04:36 GMT -5
Jill,
That is very interesting! Prions, yes, great possiblity of new diseases/infections etc.... improper folding of proteins etc, with envelopes of viruses etc. (if I have that correct)
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Post by Jill on Jul 10, 2009 11:34:20 GMT -5
You have that right Toni- improper folding of prions. What is interesting, IMO, is that E-coli acts a sample- or a example for the 'folding' of prions, for other prions to fold. Also interesting- from the old posts on this board: This was my post- LB: WOW! I just read an article by Mark Purdey- Key words- re: heat resistant fibrils of TSE (or BSE) Mad Cow/Alzheimers- 800 degrees c- which is about 1400 degrees Fahrenheit- Same as Hildy Staninger mentioned www.markpurdey.com/news_the_cause_of_bse.htmExcerpt: My hypothesis therefore asserts that the rogue metal micro-crystal represents the transmissible, pathogenic agent that underpins the primary cause of TSE diseases. This theory explains many of the missing links in our understanding of the pathogenesis of TSEs. For instance, nobody yet understands why TSE can still be invoked in misfortunate healthy lab animals after they have been injected with the inorganic ash that results from the heating of TSE affected brain material up to temperatures as high as 800 degrees C. How can the various protein-only/microbiological agents that have been ascribed to the cause of TSEs begin to survive these kind of elevated temperatures; and then retain their so called hyper-infectious property thereafter?end excerpt If memory serves- the rogue metal micro crystals Mark Purdey mentions are sourced from organophosphates. Purdey had the answers. Jill
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Post by toni on Jul 10, 2009 11:44:32 GMT -5
Sounds very plausible and a great possibility too.
Because of the 'weirdness' of Morgs, and the "keep on keepin on ability" of it...it really does seem like a path/lead for sure.
You know, something my daugther told me yesterday that I'm finding extremely interesting is this, and it's only food for thought.
It may mean nothing, or everything...who knows.
Her dog, last year, was not doing well at all. Scratching, itching, sores, hair loss ....all of that was going on.
My daughter of course took her to the vets, which of course gave her the topicals etc, shots, all that jazz to try to relieve the itching (steroids) and relieve the inflamation.
I insisted the dog had Morgellons. Of course my daughter didn't want to hear of it. (head in the sand syndrome, in that I know some believe if they ignore it - they THINK it will go away).
I see that alot from many family members. UGH That ignorance is bliss part anymore.
Well..sorry I got off what I was going to say.
I asked my daughter yesterday HOW her dog was doing?
The dog is GREAT! I said "what have you done" to turn her condition around?
She said....I simply changed her food...and her dog for a year now has been GREEEEAT ever since.
That's got me wondering now...of course.
PS...I know this sounds like an "allergic reaction to whatever the dog WAS eating"....but I want to add this in, so as to clarify why I believe this may really have something to do with Morgs.
If this were only a reaction to "the food" as an allergy would present itself ( in thinking about this) my grandaughter would now not have Morgellons....as I JUST found that out yesterday, that SHE is loaded with intense itching and sores, and her MD and Derm said it was scabies, and gave her permethrin to no avail apparently last month...and now she's even a bigger mess my daughter said with the sores, to the point of hiding it wearing long pants in this summer heat.
I felt (last year) the dog had morgs, and now my grandaughter has what seems like morgs. My daughter, in her 30's now has to have a hysterectomy because she just told me 3 days ago something is very wrong, but they don't know what yet.
So...( I can't help but think in the line or area of something's in the food).
Just sharing.
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Post by Jill on Jul 10, 2009 11:57:51 GMT -5
Sorry to read about your granddaughter, Toni. It always seems to hurt worse when you hear about the children with this condition. As to the dog, my dog will not eat dog food either. Started a few years back with the Chinese/melamine deal. The animals know, somehow. Found one of last years Purdey links: lymebusters.proboards.com/index.cgi?action=display&board=rash&thread=9496&page=1 His information is KEY for us, IMO Jill
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Post by toni on Jul 10, 2009 12:34:14 GMT -5
Thank you Jill.
I'll definately read up on this...it's got my interest big time.
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Post by beckybailey on Jul 10, 2009 13:27:20 GMT -5
looks like there are several things that can cause pigmentation changes in the skin, see table. Interesting article. www.spintrap.com/72rev.htm"Curzon(4), -who noted an intriging correlation between the chronic presence of substances having electron-transfer properties, e.g., in phenothiazine treatment or manganese poisoning, and the appearance of movement disorders (dyskinesias) in man. It has been noted (6) that disorders associated, with the chronic presence of electron-transfer agents are also typically characterized by either or both of two additional symptoms- schizophrenaia-like psychosis or pigment . abnormalities.: The occurrence, significance, and possible etiology of such coincident signs in relation to the common electronic property of the compounds involved in their production are discussed."
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Post by lilsissy on Jul 10, 2009 18:51:55 GMT -5
Polymers in motion.
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Post by Jill on Jul 10, 2009 21:36:56 GMT -5
You are welcome Toni- now with this info about Lyme and Manganese- added to the info from Mark Purdey- looks like we have a connection.
The E-coli factors in as well- will post on that tomorrow-
Jill
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Post by bannanny on Jul 12, 2009 2:13:03 GMT -5
Wow... lots of info here I'd never read before... or I forgot that I did! I'm not sure what you meant about the pix toni... I don't know what type of microscope was used to take them tho. All I know is they looked like freaky and rhorns pics to me. I sure am sorry to hear about your grandaughter too. Jills right... it hurts alot more whenever we hear of a child with this. I think we all know now that whatever morgellons is, it's in the food. I see it in most everything I eat anymore. It sure doesn't make it any easier huh? Like you said ((BB))... it really is a mystery tho. I'm glad you emailed Dr. Norgard... maybe he can help us eh? I have shown pics of springtails before. Some of them were very strange too... the one below looks like it was trying to be a springtail but morgs got to it. It might have been a mutation too... This one looks like it never had a chance... and I don't quite know about this next "thing" but it looks like it could've been a springtail in the making (or a replication of one)... This manganese thing on the other hand is gettin pretty interesting... and what's this spongiform disease? Would it have anything to do with stevefreys sponge theory? It sounds like Mark Purdy was becoming a threat to someone out there with his house burning down to the ground and his attorney being killed just before he was about to present a discovery. I don't know why, but I find it strange that he died of a brain tumor. I've come to the conclusion we're fighting something here that's not gonna go away easily... if ever. Thanks for all these interesting posts you guys. There's alot I don't understand about anything anymore... my brain has up and walked away I think. So it takes me awhile to digest it all. That's why when something hits me real hard, I put it out here...so you brainiacs can take it from there! It's sounding good too. hugs ~~ bannanny
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Post by toni on Jul 12, 2009 9:14:41 GMT -5
Thank you Bannanny about your concern. And you're wondering about those (pics what I meant)? Sorry if I'm not typing like I'm trying to say...sometimes it's really not the same. Okay...Rhorn and Freaky and others (have seen these "segmented" or "chain like" looking specimens that look like ================ as they've got the pics here. They've said here on the board they are macroscopic, which they can see them without even a microscope. Now the "borrelia" bacteria are so minute, we'd need a super dooper scope to even see that. So "those chains" can't be Borrelia, because well...that doesn't make sense, hahah (don't know how else to say it). I don't believe even many doctors have scopes to see bacteria...and I don't think any of us do. I could be wrong, but if we can see any specimens "under the scopes we're using"...it's not borrelia, especially with a childrens scope as many of us are using (the QX5's). Those no way can see bacteria of any kind. (whomever posted those chains) from the Lymephotos 2002 and stated they're borrelia, is incorrect, as borrelia invade "blood cells"...and we can't even see with our scopes (blood cells). Let alone have visible to the naked eye, chains of whatever those are. I guess what I'm trying to say is (whatever we are seeing, and taking pictures of, is no way any bacteria). PS, your second pic there, sure is a great pic of some insect in it's development it appears. Where did that come from on you? Thanks.
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