Post by lilsissy on Dec 27, 2009 20:22:47 GMT -5
getting it organized X.M.R.V.
« Thread Started Today at 8:11pm »
--------------------------------------------------------------------------------
I truly hate what I am about to write .
I am seeing some stong connections between X.M.R.V. and Morgellons.
XMRV has been linked to Chronic Fatigue /Fibromyalagia and Cancer.
We have certainly have had Cancer related deaths and also many of us have Chronic/Fatigue and Fibromyalgia. health.google.com/health/ref/Fibromyalgia
In investigating this XMRV I have noticed many simularities.
I have noticed many of us carry very high VIRAL LOADS, HERPES and EPSTEIN BARR.
X.M.R.V. shuts down the bodies response to viruses. It is indeed a very stange virus itself.
I wonder is Morgellons, C.F., Fibro and Cancer....... a by-product of an unintended Agrobacterium mediation that was intended for plants?
I know that my family also carries a 1q42 mutation with Kartengers Syndrome , because my daughters heart and chest organs are reversed .
I do not know for sure exactly how this fits in but I think many of us on this board have this gene mutation spot.
It is a spot that has a gap that allows for a gene insertion to be put in . I believe it is the most common and biggest naturally occuring gap area in the Human genome. It allows for the insertion of added genes. It is called Trisomy , a third gene , an added gene.
You can not tell by looking at my daughter that she has this added gene . She is beautifull and very very smart. Some children born this way are retarded some are not.
This area 1q42 with Kartengers syndrome often results in a incomplete form of cystic Fibrosis when it is not fully displayed in carriers of that gene . I am a carrier , being the mother of this daughter and my sister also has situs abnormalities, this gene runs in the family.
This would explain why we have trouble with Agrobacteium infections to begin with. Agrobacterium is know to be an infection in Cystic Fibrosis Patients.
1 in 25 people are silent carriers of this gene mutation for cystic fibrosis . In studying this gene mutation , the 1Q42 area , I also found that it is the same area responsible for early-onset Prostate cancer.
I think this is just too much to be a co-incident,
I believe more than ever Morgellons sufferers have an added gene mutation in the area of 1q42 which may be the result of an agrobacterium infections and / or makes us more susceptable to agrobacterium infections thus High Viral Loads and Cancer.
This virus XMRV is also implicated in prostate cancer , early prostate cancer is also linked to 1q42,
www.cell.com/AJHG/abstract/S0002-9297(07)62783-9
So somehow, 1q42 with Kartengers and
X.M.R.V. are in connection with one another.
Off the top of my head they both have added genes in this gap area.
XMRV was discovered by laboratories led by Joseph DeRisi at the University of California, San Francisco, and Robert Silverman and Eric Klein of the Cleveland Clinic. Silverman had previously cloned and investigated the enzyme ribonuclease L (RNase L), part of the cell’s natural defense against viruses. When activated, RNase L degrades cellular and viral RNA to halt viral replication. In 2002, the “hereditary prostate cancer 1” locus (HPC1) was mapped to the RNase L gene, implicating it in the development of prostate cancer.[5] The cancer-associated “R462Q” mutation results in a glutamine instead of an arginine at position 462 of the RNase L enzyme, reducing its catalytic activity. A man with two copies of this mutation has twice the risk of prostate cancer; one copy raises the risk by 50%.[2]
Prostate Cancer May Be Linked to Virus - RNASEL Gene Defends against Viruses
February 24th 2006
Comon Flu Viruses
Researchers at the Cleveland Clinic and the University of California San Francisco have identified a new virus in human prostate tumors. They are not sure whether this virus is linked to prostate cancer yet.
The virus was found more often in human prostate tumors with two copies of the RNASEL gene mutation than in tumors with at least one normal copy of the gene, Forbes reported. Dr. Eric Klein said "This is a virus that has never been seen in humans before. This is consistent with previous epidemiologic and genetic research that has suggested that prostate cancer may result from chronic inflammation, perhaps as a response to infection." Dr. Klein is head of urologic oncology at the Cleveland Clinic's Glickman Urologic Institute.
The researchers say that RNASEL is a gene that serves as an important defense against viruses. Scientists have suspected that this gene mutation and virus may be responsible for some types of cancer.
The scientists used a new “virus chip” to identify the virus. This chip was used three years ago to confirm the identity of the SARS virus. Klein says this finding validates the use of the virus chip to discover previously unknown viruses. This may help us learn more about viral causes of disease.
There are other cancers that may be caused or related to viruses. Liver and cervical cancer could be caused by a virus. Now scientists are investigating whether diseases may play an important role alongside genetics in causing breast, stomach and several other forms of cancer. There are environmental concerns as well. Future treatments and possible preventative measures may include enzymes that help kill invading viruses.
Virus-Induced Gene Silencing, a Post Transcriptional Gene ...by U Turgay - 2009 - Cited by 1 - Related articles - All 9 versions
Virus-induced gene silencing (VIGS) is one of the reverse genetics tools for ... an RNAse-like enzyme, are then incorporated into RNA-induced silencing .... The TRV silencing in plants is usually mediated by Agrobacterium tumefaciens. ..... virus-induced gene silencing in chili pepper (Capsicum annuum L. cv. ...
www.hindawi.com/journals/ijpg/2009/198680.html - Cached
US Patent 5589625 - Transgenic plants displaying multiple virus resistance and a process for their production
US Patent Issued on December 31, 1996
Estimated Patent Expiration Date: January 18, 2015Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Abstract Claims Description Full Text
View Patent Images (PDF)
(Registered users only)
Description
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to transgenic plants that are genetically engineered to contain a DNA sequence encoding at least one polypeptide having a 2,5A synthetase activity thereby providing to said plants resistance against multiple taxonomic virus types. Moreover, this invention relates to a process for the production of said transgenic plants and to the use of said genetically engineered DNA sequence.
2. Description of Related Art
Several methods for the construction of virus resistant plants are described in the state of the art. Genetically engineered resistance to a number of plant viruses has been reported by expressing coat protein of a respective plant virus in transgenic plants (Beachy, et al., Annu. Rev. Phytopathol., 28:451-474, 1990).
A substantial virus-resistance to several plant viruses has also been demonstrated by expression of specific viral antisense RNA in transgenic plants (Cuozzo, et al, Bio/Technology, 6:549-557 1988; Hemenway, et al., EMBO J., 7: 1273-1280, 1988). The viral antisense RNA exhibits its function either by hybridizing to specific viral DNA or RNA sequences and thus blocking further reactions which are important for the virus propagation, or by ribozyme activity which results in a specific cleavage of viral RNA upon hybridization to said viral RNA.
I am still working on this theroy and how it all fits together but it does seem unfortunately does seem to fit together.
Notice this chip, hmmmmmm
Jen
Will it tell us of added genes ?
« Thread Started Today at 8:11pm »
--------------------------------------------------------------------------------
I truly hate what I am about to write .
I am seeing some stong connections between X.M.R.V. and Morgellons.
XMRV has been linked to Chronic Fatigue /Fibromyalagia and Cancer.
We have certainly have had Cancer related deaths and also many of us have Chronic/Fatigue and Fibromyalgia. health.google.com/health/ref/Fibromyalgia
In investigating this XMRV I have noticed many simularities.
I have noticed many of us carry very high VIRAL LOADS, HERPES and EPSTEIN BARR.
X.M.R.V. shuts down the bodies response to viruses. It is indeed a very stange virus itself.
I wonder is Morgellons, C.F., Fibro and Cancer....... a by-product of an unintended Agrobacterium mediation that was intended for plants?
I know that my family also carries a 1q42 mutation with Kartengers Syndrome , because my daughters heart and chest organs are reversed .
I do not know for sure exactly how this fits in but I think many of us on this board have this gene mutation spot.
It is a spot that has a gap that allows for a gene insertion to be put in . I believe it is the most common and biggest naturally occuring gap area in the Human genome. It allows for the insertion of added genes. It is called Trisomy , a third gene , an added gene.
You can not tell by looking at my daughter that she has this added gene . She is beautifull and very very smart. Some children born this way are retarded some are not.
This area 1q42 with Kartengers syndrome often results in a incomplete form of cystic Fibrosis when it is not fully displayed in carriers of that gene . I am a carrier , being the mother of this daughter and my sister also has situs abnormalities, this gene runs in the family.
This would explain why we have trouble with Agrobacteium infections to begin with. Agrobacterium is know to be an infection in Cystic Fibrosis Patients.
1 in 25 people are silent carriers of this gene mutation for cystic fibrosis . In studying this gene mutation , the 1Q42 area , I also found that it is the same area responsible for early-onset Prostate cancer.
I think this is just too much to be a co-incident,
I believe more than ever Morgellons sufferers have an added gene mutation in the area of 1q42 which may be the result of an agrobacterium infections and / or makes us more susceptable to agrobacterium infections thus High Viral Loads and Cancer.
This virus XMRV is also implicated in prostate cancer , early prostate cancer is also linked to 1q42,
www.cell.com/AJHG/abstract/S0002-9297(07)62783-9
So somehow, 1q42 with Kartengers and
X.M.R.V. are in connection with one another.
Off the top of my head they both have added genes in this gap area.
XMRV was discovered by laboratories led by Joseph DeRisi at the University of California, San Francisco, and Robert Silverman and Eric Klein of the Cleveland Clinic. Silverman had previously cloned and investigated the enzyme ribonuclease L (RNase L), part of the cell’s natural defense against viruses. When activated, RNase L degrades cellular and viral RNA to halt viral replication. In 2002, the “hereditary prostate cancer 1” locus (HPC1) was mapped to the RNase L gene, implicating it in the development of prostate cancer.[5] The cancer-associated “R462Q” mutation results in a glutamine instead of an arginine at position 462 of the RNase L enzyme, reducing its catalytic activity. A man with two copies of this mutation has twice the risk of prostate cancer; one copy raises the risk by 50%.[2]
Prostate Cancer May Be Linked to Virus - RNASEL Gene Defends against Viruses
February 24th 2006
Comon Flu Viruses
Researchers at the Cleveland Clinic and the University of California San Francisco have identified a new virus in human prostate tumors. They are not sure whether this virus is linked to prostate cancer yet.
The virus was found more often in human prostate tumors with two copies of the RNASEL gene mutation than in tumors with at least one normal copy of the gene, Forbes reported. Dr. Eric Klein said "This is a virus that has never been seen in humans before. This is consistent with previous epidemiologic and genetic research that has suggested that prostate cancer may result from chronic inflammation, perhaps as a response to infection." Dr. Klein is head of urologic oncology at the Cleveland Clinic's Glickman Urologic Institute.
The researchers say that RNASEL is a gene that serves as an important defense against viruses. Scientists have suspected that this gene mutation and virus may be responsible for some types of cancer.
The scientists used a new “virus chip” to identify the virus. This chip was used three years ago to confirm the identity of the SARS virus. Klein says this finding validates the use of the virus chip to discover previously unknown viruses. This may help us learn more about viral causes of disease.
There are other cancers that may be caused or related to viruses. Liver and cervical cancer could be caused by a virus. Now scientists are investigating whether diseases may play an important role alongside genetics in causing breast, stomach and several other forms of cancer. There are environmental concerns as well. Future treatments and possible preventative measures may include enzymes that help kill invading viruses.
Virus-Induced Gene Silencing, a Post Transcriptional Gene ...by U Turgay - 2009 - Cited by 1 - Related articles - All 9 versions
Virus-induced gene silencing (VIGS) is one of the reverse genetics tools for ... an RNAse-like enzyme, are then incorporated into RNA-induced silencing .... The TRV silencing in plants is usually mediated by Agrobacterium tumefaciens. ..... virus-induced gene silencing in chili pepper (Capsicum annuum L. cv. ...
www.hindawi.com/journals/ijpg/2009/198680.html - Cached
US Patent 5589625 - Transgenic plants displaying multiple virus resistance and a process for their production
US Patent Issued on December 31, 1996
Estimated Patent Expiration Date: January 18, 2015Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Abstract Claims Description Full Text
View Patent Images (PDF)
(Registered users only)
Description
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to transgenic plants that are genetically engineered to contain a DNA sequence encoding at least one polypeptide having a 2,5A synthetase activity thereby providing to said plants resistance against multiple taxonomic virus types. Moreover, this invention relates to a process for the production of said transgenic plants and to the use of said genetically engineered DNA sequence.
2. Description of Related Art
Several methods for the construction of virus resistant plants are described in the state of the art. Genetically engineered resistance to a number of plant viruses has been reported by expressing coat protein of a respective plant virus in transgenic plants (Beachy, et al., Annu. Rev. Phytopathol., 28:451-474, 1990).
A substantial virus-resistance to several plant viruses has also been demonstrated by expression of specific viral antisense RNA in transgenic plants (Cuozzo, et al, Bio/Technology, 6:549-557 1988; Hemenway, et al., EMBO J., 7: 1273-1280, 1988). The viral antisense RNA exhibits its function either by hybridizing to specific viral DNA or RNA sequences and thus blocking further reactions which are important for the virus propagation, or by ribozyme activity which results in a specific cleavage of viral RNA upon hybridization to said viral RNA.
I am still working on this theroy and how it all fits together but it does seem unfortunately does seem to fit together.
Notice this chip, hmmmmmm
Jen
Will it tell us of added genes ?