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Post by zabrubon on Mar 2, 2007 0:15:58 GMT -5
. Impediments at the wound surface. This may include high bacterial counts, closed wound edges, high-volume exudate, or drying of the wound surface.1'4'6 A particularly common problem is bacterial counts on the wound surface that are high enough to interfere with the repair process. Surface-level infection is indicated by persistent high-volume exudatc, sudden deterioration in the quantity or quality of granulation tissue, repeated formation of a thin layer of avascular tissue, and increased pain.
Clinicians should note that surface-level infection does not manifest as erythema, edema, and induration of the surrounding tissue. Patients with evidence of surface level wound infection (also known as critical colonization) may benefit from the addition of a topical antibacterial, such as cadexomer iodine, a sustained release silver dressing/or silver sulfadiazinc.
4. An imbalance in the mix of regulatory substances governing repair? Current research shows that wound healing is regulated by a complex interplay among growth factors, inflammatory mediators, cytokines (eg, nitric oxide), and hormones; an imbalance among these factors can create a nonhealing wound even when causative factors, systemic factors, and local wound factors have been addressed
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Post by zabrubon on Mar 2, 2007 0:23:14 GMT -5
gREAT WEBSITE ON IMMUNE SYSTEM WITH TUTORIALS
microvet.arizona.edu/Courses/MIC419/Tutorials/cytokines.html
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