Post by kammy on Apr 27, 2009 15:35:54 GMT -5
THE NEW QUORUM SENSING ANTIBIOTICS and THE ANTIFUNGALS:
Kammy,
there is this german wikipedia site which is always a little different in information than the english one.
Damn! I need to translate.
...
Die ersten Organismen, in denen Quorum sensing beobachtet wurde, sind die komplexen Myxobakterien und Spezies aus der Gattung der Streptomyceten. Am bekanntesten ist jedoch die Biolumineszenz von Vibrio fischeri, eine Bakterienart, die als Symbiont in den leuchtenden Organen einer Sepiaart lebt. Freilebende Bakterien dieser Art erreichen nicht dieselbe Konzentration wie innerhalb dieser Organe, weshalb sie dort nicht leuchten.
Streptococcus pneumoniae nutzt Quorum sensing, um Kompetenz zu erreichen.
Beim dimorphen Pilz Candida albicans wirkt Farnesol als Quorum-sensing-Molekül. Es hemmt bei hoher Populationsdichte das Hyphenwachstum.
It says...well don't expect too much..it's not easy for me, but I'll try.
Here we go:
The first organisms which has shown Quorum sensing are the complex
Myxobacteria and species from Streptomyces. The most known bacteria is Vibrio fischeri (a grammnegative bacteria which lives in the OCEAN!) which has bioluminescence..a bacteria which lives as a symbiont in the glowing
organs of a sepia. Free living bacteria cannot reach this high concentration like in the organs that's why they don't glow.
Streptococcus pneumonae uses Quorum sensing to reach capacity.
With the dimorph fungus Candida albicans Farnesol works as a quorum sensing molecule. It blocks the hyphae growth by high population.
As you can see there are bacteria and marine organisms involved here together with fungi. The whole bunch!
Biotechdaily - New Generation of Antibiotics Disrupts Quorum Sensing - Online bioresearch news
biotechdaily.com/?option=com_article&Itemid=294722535&cat=Drug%20Discovery
...cells are forming a biofilm – a colony of bacteria that contains resistant organisms and is involved in many antibiotic-resistant infections – they perform a function that enables them to leave a unique imprint on the world: their DNA. A small percentage of cells explode in a process called “lysis,” leaving behind a sticky residue that contains DNA and other cellular bioproducts which are then incorporated into the larger cell community to build a stronger biofilm.
New Hope For Fighting Antibiotic Resistance
www.sciencedaily.com/releases/2007/04/070426135314.htm
This disease has also something to do with anitibiotic overuse and antibiotic resistance I think.
Antibiotic Compounds That Bacteria Can't Resist
www.scientificblogging.com/alternate_allele/antibiotic_compounds_bacteria_cant_resist
Methylthioadenosine nucleosidase
Methylthioadenosine nucleosidase - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase
Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa.
www.ncbi.nlm.nih.gov/pubmed/18644954
Effects of antibiotics on quorum sensing in Pseudo...[Antimicrob Agents Chemother. 2008] - PubMed Result
....The effects of the three antibiotics administered at subinhibitory concentrations were investigated by use of DNA microarrays. Consistent results from the virulence factor assays, reverse transcription-PCR, and the DNA microarrays support the finding that AZM, CFT, and CPR decrease the expression of a range of QS-regulated virulence factors.
....Three of the antibiotics tested, AZM, ceftazidime (CFT), and ciprofloxacin (CPR), were very active in the assay and were further examined for their effects on QS-regulated virulence factor production in P. aeruginosa.
Jeany
THE NEW QUORUM SENSING ANTIBIOTICS
Theoretically, these new quorum sensing antibiotics should help with a fungal infection because ALL of these, bacteria, fungus, etc., are using the same enzyme to communicate. These new antibotics make these bacteria and fungus - deaf, dumb and blind so they can't continue to reproduce and therefore - die.
HOWEVER... these may not be enough without an antifungal - because we don't know yet exactly what we're dealing with? The antifungals listed below as per Jeany's research, also.
An antifungal alone may not be enough, because possibly, if there are nematodes involved - they are producing bacterial waste? According to Sarothra - What is seen as the "cherry red" that looks like blood, called 'PL' but is actually the bacterial, by-product waste of the nematode 'HB'.
As per Jeany's research in a quote from the Crypto thread - and thank you, Jeany for your hard work - Jeany is key here folks, she is in Germany with Morgellons and Lyme's? and is working very hard to help us solve this.
THE NAMES OF THESE NEW ANTIBIOTICS ARE:
(as per Jeany's research):
...."Three of the antibiotics tested, AZM, ceftazidime (CFT), and ciprofloxacin (CPR), "[/b]
EFFECTIVE ANTI-FUNGALS
We need some science to figure out what's going on. Insist on a Mycology Report, don't just accept an antifungal prescription without some testing involved. However, if you can't get tested these anti-fungal drugs have been recommended by Mark Newmann and Jeany researched them today and this is her post:
Voricanozole and Posacanozole are quite expensive and I'm afraid some of your US docs won't or can't prescirbe these. I don't know for sure though ofcourse....but worth asking for them.
Caspofungin and Itraconazole might be helpful ....and cost less. Although these antifungals are not as effective.
Yes; Marc Neumann mentions these on his site too.
Caspofungin: Caspofungin - Wikipedia, the free encyclopedia
Itraconazole: Itraconazole - Wikipedia, the free encyclopedia
Voricanozole: Voriconazole - Wikipedia, the free encyclopedia
Posacanozole: Posaconazole - Wikipedia, the free encyclopedia
Note: Voricanozole and Posaconazole are antifungals for invasive fungal infections in immunocompromised patients.
Posaconazole also treats Fusarium infections.
Jeany
Caspofungin and Itraconazole might be helpful ....and cost less. Although these antifungals are not as effective.
Yes; Marc Neumann mentions these on his site too.
Caspofungin: Caspofungin - Wikipedia, the free encyclopedia
Itraconazole: Itraconazole - Wikipedia, the free encyclopedia
Voricanozole: Voriconazole - Wikipedia, the free encyclopedia
Posacanozole: Posaconazole - Wikipedia, the free encyclopedia
Note: Voricanozole and Posaconazole are antifungals for invasive fungal infections in immunocompromised patients.
Posaconazole also treats Fusarium infections.
Jeany
THE ANTIFUNGALS ARE:
"Note: Voricanozole and Posaconazole are antifungals for invasive fungal infections in immunocompromised patients."