Methylation

[fritolay66]

METHYLATION

Multiple factors absolutely influence an individuals susceptability to disease. Environmental toxins including mold exposures, exposure to infectious agents and the endotoxins they can create, as well as underlying genetic susceptibility to disease, or genotypes. There are varying genotypes by which expression or suppression occurs within the genetic make up of an individual and confers their susceptibility or resistance to differing diseases. (1)

The precise combination of components that interact to cause multifactorial diseases can be very different from individual to individual. There may be slight or enormous changes in the relative contributions of each of the factors to disease. I believe this is the explanation for the differences between those of us with Morgellons.

I also believe that many of us are suffering from toxicity or biotoxin issues. Varying but none the less, by looking at the MRF’s testing and the commonalities found in those published on it site, those tests reflect biotoxin disease and the abnormalities associated with it. See link here for the common abnormalities found in Morgellons patients.

www.morgellons.org/case_definition.htm

Due to those common lab abnormalities found in their case studies, I also believe methylation may have a definitive role in our disease but I have yet to hear it talked about on Morgellons boards. I’d like to introduce it here today and the information I have found on it.

Methylation is not just one specific reaction as there are hundreds of “methylation” reactions in the body. Methylation is simply the addition or subtraction of a methyl group to a compound or element within the body and the systems within the body that depend on this reaction. A methyl group is one carbon connected to three hydrogen atoms and can be written as CH3. (1) You will find some sources cite re-methylation and that specific terminology refers to the addition of a methyl group to a substrate or element.

In general, when some compounds receive a methyl group, this starts a reaction, such as turning on a particular gene or activating an enzyme which is incredibly important in the body detoxification mechanisms. When the methyl group is "lost" or removed, the reaction stops, or a gene is turned off or the enzyme is deactivated. (3) This can be bad when we lose our ability to detoxify. I believe this is what some of us are experiencing, the loss or removal of methyl groups through our illness in the cytokine responses I have previously posted on. And if loss of methylation is occurring, this would have huge ramifications on our health, immunity, and genetic traits.

Follow the links I have provided. There are one or two on the techy side, the rest are what I call easy reading.

www.enzymestuff.com/methylation.htm

tinyurl.com/2un5vou

tinyurl.com/3674apq

www.genetics.org/cgi/content/full/174/3/1161

www.ncbi.nlm.gov/pubmed/16729250

tinyurl.com/2ug9x8g

www.pwsdots.org/w/index.php?title+Vitamin_B12

www.pwsdots.org/w/index.php?title=Folic_acid

www.articlesbase.com/print/3002403

www.en.wikipedia.org/wiki/Methylation

This has everything to do with gene expression, gene deletion, rNA, detoxification systems in the body, enzymes, amino acids, proteins, prions, MCS, and the many diseases they are finding these commonalties in. Fibromyalgia, CFS, MS, Alzheimers, Lyme, Depression disorders, etc. I feel this is most definately a contributor in our disease as well and very dependent on our own genetic codes.

Frito

[kammy]

This is good, Frito, I'm glad that those with the medical backgrounds or knowledge are running with the ball to try to help us, ty. Methylation and biotoxins... yes.

[fritolay66]

I also found this about skin lesions and the Vitamin B Deficiency issue.

www.ncbi.nlm.nih.gov/pmc/articles/PMC2294086/

A patient presenting with cutaneous lesions alone should make us highly suspicious of the possibility of vitamin B12 deficiency. We should be more aware that cutaneous lesions not responding to conventional therapy could very likely be an indication of vitamin B12 deficiency. These skin manifestations respond quickly to vitamin B12 therapy. Early treatment with vitamin B12 will prevent the serious complications of vitamin B12 deficiency.

Editors Key Points:

•Skin lesions associated with vitamin B12 deficiency are skin hyperpigmentation, vitiligo, angular stomatitis, and hair changes.

•Cutaneous lesions that do not respond to conventional therapy can be an indication of vitamin B12 deficiency.

•Malabsorption is the most common cause of vitamin B12 deficiency. Initial replacement is usually through intramuscular injections. Those with normal absorption can be maintained on oral replacement.

Frito

Ongoing discussion at MDR.

tinyurl.com/2bbmkbc

[jj]

Frito

You continue to amaze me. Thank you for all you do. I wish I was able to contribute more to your efforts. Good job.

JJ

[Lynn]

Wow Fritto

Thank you. Wish I had been reading more back when this was posted.

How far along are you in the Methalation? How many months and if any problem you ran into. I know of another person that is also doing his Methalation pathways through a Dr. and a Neoropath (sp). I eventually want to get there also. I really think this is the big link between all of us with Toxic syndrom and Morgellons.

In Light Lynn

[22122agin]

Hi Lynn and frito,
Here is a good link that maybe you all know already. It will take you to the board and the poster who is Methylation expert but not an MD is posts as richvank.

Here is just a sample of one of his responses. If you want to do a search on this board, its the ME/CFS board within Prohealth community that you have to sign on to. For someone like me, doing the protocol is very dicey as I have zero glutathione because that is what Lyme disease does. There are ways around it. Likely kammy knows about this site.
A complicated subject. I can't take TMG for example.
22122

www.prohealth.com/me-cfs/blog/boardDetail.cfm?id=1409318

[fritolay66]

Lynn,

I am six months into the protocol.

I have run into lots of problems with the protocol, and still sorting out some now. But ask me how I am doing. ;D

Yes, I believe I know the person whom you refer to and the physician. And to this person...my very best!!

Hello 22122agin and thank you. Yes, Phoenix Rising is the sister board to the Prohealth board. They are both ME/CFS.

I would like to nudge everyone to get out of your morgellons comfort zone and go to some of these other boards and learn.

Frito

[frappergirl]

:)Thanks Frito that's a great study. For sure we all have a family history. ;D
For what its worth it my thought that today's answer to disease is the study of the body on a whole--Environmental,Chemical,Gmo foods,Processed foods,Microwave ovens,plastic drinking bottles,etc etc,and what we have been handed through our heritage and the gene pool.

Methylation pathway study is fascinating and those of us with disease challenges, compromised immune systems, and blocked pathways need to look at our toxic body level load and our own bodies ability to clear out those toxens.
For instance a person may have a genetic pre-disposition to Folac Acid and their body system may not be able to absorb regular Folac Acid so they may need a methylated form known as L-5 Methyltetrahydrofolate.

We with morgellons are in a disease group much like those with such things even as Autism, and may share a common problem with methylation pathways.
There is a Dr Amy who treats Autism, her site is online,and she has a brilliant diagram of the Methylation pathway.
The diseased body systems are blocked with numerous toxins and a body that cannot properly move the toxens out of the system.

If you see those with such diseases as Autism and you would look at a cross section of their intestinal tract(such as in a cystoscopy you would see in a cross section picture of that colon that the colons full of blockage,and looks like a pipe with years of build up.
This due from exposure to those things that are toxic.Some of which are (chemicals in our environment,processed foods,GMO foods,etc,etc)
I am really generalizing of course.
We with morgellons are much the same,our body systems are in need of re-balancing of compounds,gentle house cleaning,opening of drains, and healing.
I saw the after photo of the Autistic person after their practitioner started working on their all over body system(practitioner also supporting the weakened areas with balanced needed supplementation,or medication if indicated ) you see a marked difference in the new cross section of the colon..but,the practitioner approached the cleaning with a gradual well planned building of terrain and balancing of compounds ,with a process that was determined by periodic evaluation of the patient.
I think the gut and our plumbing gone untreated can cause brain fog,fatigue,and also bacterias/yeast in the overgrowth or bio film that has been building for years.
I've seen friends pound their systems with 'good supplements' only to get sicker..why?
I think probably personal family history(which would include the genetic pre dispositions)was not considered or checked,and they had years of bio film gone untreated - so the supplements bounced around inside and actually blocked their pathways even more.
I believe the new medicine may even start with Dna testing,Genetic markers, and checking the bodies level of toxic stress- - first.

FrapperG

[22122agin]

frapperG,
I think one thing about supplements is to take them just one to test over a few days with no other supplements and test each one that way. Otherwise you won't find out that maybe you can't take R-lipoic but can take the L-form and have a heck of a time with NAC. You can't make the body accept what it can't seem to handle because of damaged pathways or whatever. Most doctors don't realize this though well meaning and you leave the office with 99 percent of stuff you can't take and empty pocket book also. I try to buy from supplement places with a good return. They are used to me returning and I always write them a report what went down with me with symtoms.
Thanks for your post.
22122

[frappergirl]

Hi 2212 again!I so agree!
If you have Functional medicine testing it will show you which supplements you can and cannot take.
That really saves on the pocket book and I, like you have wasted pockets o money on things that can't be used.


FrapperG

[22122agin]

Hi FrapperG,
I have had testing there i hold a probe and the supplement is set on a plate on the machine and depending where the dial goes the supplement is ok for me. I also have had doctors including me, do muscle testing and also pendulum testing including doing this part myself. Is Functional testing something other than this? Can you illuminate? I would save a lot on shipping maybe sending supplements back and forth.
Thanks!
22122

[frappergirl]

Hi*ok :Ddo my best.

Tomorrow please? Im bushed tonight just wanted to stop and say hi.
Will you Pm me to remind me
To begin 3 functional med. tests would be 1.Hair anaylisis for heavy metals2. Oat urine 3. DNA stool test
Please pm me and I will do a better job tomorrow- K?

FrapperG