Post by adapted on May 30, 2005 7:50:27 GMT -5
What is the basic definition of Th1 inflammation?
Dr. Trevor Marshall says:
"Th1 is short hand for "T-helper cell type 1" which is a state of activated CD4+ T lymphocytes thought to be behind an immune response which is characterized by a cytokine profile slightly different from the body's normal response to viruses, funguses, etc, a profile which is strong in a cytokine called Interferon-gamma.
The Th2 immune reaction of a healthy body does not generate much Interferon-gamma.
This is important, as the Th1 immune reactions often are thought of as an 'over-active' immune system, because the Interferon gamma, and the 1,25-dihydroxyvitamin-D it generates, cause extra mast cells to differentiate to monocytes (primitive white cells) and then to further differentiate (grow) into macrophages and dendritic cells, the most active phagocytes of the immune system, those cells which are charged with the job of digesting bacterial pathogens.
What I discovered was that when the phagocytes themselves become parasitized by CWD variants of certain bacterial pathogens, it is the pathogens which determine the body's immune response, not the T lymphocytes. The Th1 lymphocyte excitation is really a result of the intra-cellular infection, and not a response to extra-cellular bacteria. This is because the bacteria within the cytoplasm of the phagocyte can directly force the nucleus of that cell to produce the Th1 cytokines, presumably as an advanced defense against the host (human).
There is more info about this in our paper "Sarcoidosis succumbs to antibiotics - implications for autoimmune disease" at URL tinyurl.com/5rgmq
The free full text of that paper is available at
yarcrip.com/sarcoidosissuccumbs-preprint.htm
I hope this helps, it is quite a complex topic, and the solution had eluded science for at least 50 years "
for more information about the Immune System you can order the DVDs 'Recovering from Chronic Disease' derived from Our Chicago Conference @ our AutoImmunity Research Website. Here Dr Marshall explains how the immune system is perverted by the bacteria. and the "Familial Aggregation" presentation also deals with the genetic predisposition issue in detail.
www.marshallprotocol.com/
Dr. Trevor Marshall says:
"Th1 is short hand for "T-helper cell type 1" which is a state of activated CD4+ T lymphocytes thought to be behind an immune response which is characterized by a cytokine profile slightly different from the body's normal response to viruses, funguses, etc, a profile which is strong in a cytokine called Interferon-gamma.
The Th2 immune reaction of a healthy body does not generate much Interferon-gamma.
This is important, as the Th1 immune reactions often are thought of as an 'over-active' immune system, because the Interferon gamma, and the 1,25-dihydroxyvitamin-D it generates, cause extra mast cells to differentiate to monocytes (primitive white cells) and then to further differentiate (grow) into macrophages and dendritic cells, the most active phagocytes of the immune system, those cells which are charged with the job of digesting bacterial pathogens.
What I discovered was that when the phagocytes themselves become parasitized by CWD variants of certain bacterial pathogens, it is the pathogens which determine the body's immune response, not the T lymphocytes. The Th1 lymphocyte excitation is really a result of the intra-cellular infection, and not a response to extra-cellular bacteria. This is because the bacteria within the cytoplasm of the phagocyte can directly force the nucleus of that cell to produce the Th1 cytokines, presumably as an advanced defense against the host (human).
There is more info about this in our paper "Sarcoidosis succumbs to antibiotics - implications for autoimmune disease" at URL tinyurl.com/5rgmq
The free full text of that paper is available at
yarcrip.com/sarcoidosissuccumbs-preprint.htm
I hope this helps, it is quite a complex topic, and the solution had eluded science for at least 50 years "
for more information about the Immune System you can order the DVDs 'Recovering from Chronic Disease' derived from Our Chicago Conference @ our AutoImmunity Research Website. Here Dr Marshall explains how the immune system is perverted by the bacteria. and the "Familial Aggregation" presentation also deals with the genetic predisposition issue in detail.
www.marshallprotocol.com/