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Post by ibzahp on Aug 2, 2010 16:00:17 GMT -5
Evidence of multiple infectious agents in mycosis fungoides lesions.
Bonin S, Tothova SM, Barbazza R, Brunetti D, Stanta G, Trevisan G.
ACADEM Department, Unit of Dermatology, University of Trieste, Trieste, Italy. Abstract
The etiology of mycosis fungoides (MF) remains to be determined. Several studies have proposed a viral etiology with controversial results. In this case-control study we investigated the presence of Epstein-Barr virus (EBV) and the debated presence of Human T-cell lymphotrophic virus I (HTLV-I) sequences, by polymerase chain reaction on nucleic acid extracts from formalin-fixed paraffin-embedded skin biopsies. Moreover, by a multivariate approach we analyzed in the same case-control study also the contribution of two previously examined pathogens: Hepatitis C virus (HCV) and Borrelia burgdorferi (Bb). Significant differences in the frequency of infectious agents in cases and controls were detected for Bb, HTLV-I and EBV. In MF patients we found the concurrent presence of two or three of these pathogen sequences in 21 out of 83 cases, but only in 1 out of 83 healthy controls. Our results suggest that the persistence of multiple infectious agents may cause a long-term antigenic stimulation contributing to the malignant transformation of T lymphocytes, especially when associated with HTLV-I like sequences. However, these infectious agents do not seem to have effects on disease progression. Copyright 2010 Elsevier Inc. All rights reserved.
PMID: 20470773 [PubMed - in process]
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Post by Baraka Obam on Aug 2, 2010 19:22:39 GMT -5
There are many such type, LESION/TUMORS situations, looking at the pictures of these, one picture is VERY interesting, that is the tumor stage where it has the white plastic material showing. Either they got this lesion wrong, many lesions produce the white plastic material or I may have, we may have, cutaneous, t cell, lymphoma. If you read the article and just do not look at the pictures you will see what I have been spewing for some long time, two of my G/F that had no significant problems developed spots of ALLOPECTA, here it says allopecia is CONNECTED to this situation. ALOPECIA is a fibrous material disease. Fibrous material unknown cause disease, which there are more than you can count are thought to be connected to PRIONS that have changed. Could prion change be the cause of the evolutionary process, could we be adapting to our toxic world, on the fast track. dermnetnz.org/dermal-infiltrative/cutaneous-t-cell-lymphoma.html
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Post by ibzahp on Aug 3, 2010 13:10:17 GMT -5
Also interesting that it notes changes around the hair follicles. I looked twice at the abstract because I have EBV, HCV, and Bb. A bit over my head but this can't be good news. I think you are on to something re:PRIONS. Geez this is just no fun.
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