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Post by freaky on Dec 3, 2007 4:03:54 GMT -5
Be kind to strangers, they may be angels. Roberta asked me to post this thread. Hope I did it OK, as I'm falling asleep. Warm fuzzzies for all, freaky
Hi there everyone I don't know where to start but I guess I should start with my dog Kyra Now frequently Kyra presents a very sticky substance in her coat it is translucent and I can see things is this sort of glue. Well I went out this morning and she had this stuff over one of her legs her face and some on her back. I was just horriefied I cann't stand this it is going on for much much much tooooo long. So I sat at the computer and put my thinking cap on. I am broke so cann't afford to get anything from the Vet. So I thought what have I got in my house that might help her. I always have srong disenfectant in the house. I buy it in 250ml bottles three at a time. It is only $1.20 So I looked it up on the internet to see if it was safe to put on her coat. Well it all sounded very good!!!! Not just for Kyra but for me. It is a disinfectant concentrate and the main ingredients are benzalkonium chloride 4.5% Well I got Kyra in a small bath wet her all over. I had a spray bottle of this stuff plus just a bottle of it. I used the spray bottle on her tummy and chest and tail, top of her head, inside and out side her ears and used the bottle all along her back. She is a very very very good girl in the bath. What amazed me was that my left arm (the one I use to bathe her) started itching like hell! Anyway I got Kyra done didn't wipe her down she is outside in the sun getting dried off. I will take her or a walk soon and the wind will dry her. She got an extra special treat for being a good girl. Now to my arm the itching WAS TERRIBLE after using this stuff on Kyra. I got black things and little white things and then very little tiny dots. I can see no reason why we cann't use it on ourselves. there is just one thing Kyra does not have any lesions. These things just breed in her coat and she has a double coat so this doesn't get to her skin, but the internet said that it was okay for the skin and it is quite okay on my skin, and it is not affecting Kyra she isn't running around in discomfort she is just sitting enjoying the sun waiting for her walk. As you must have realized I am not towelling her down I am letting this stuff dry in her coat. All ready I can see "things" coming our of her. I do hope that it will help your dogs and us as well. Please look it up o n the net I went to google and typed in benzalkonium chloride. I will keep you up to date on Kyras progress i don't expect anything, but it is just very very very interesting to see what comes out of her coat that cann't be seen by the naked eye. Sidney said about a week ago that this thing was a scavanger and I firmly believe her. I am amazed at what comes out of Kyras coat when we are out walking. For some reason I do not see it in her coat inside the house. It is when we are out walking in the sun light no matter how weak and the movement seems to get these things activated. Like when you have been on holiday for a few weeks and then you walk into the house and there is all these tiny fleas that attack you they are motivated by movement and that is what I see in Kyra. I hope that this helps. Please let me know if you are using it on your dogs and if you notice any difference. Much love to all. Roberta. Back to Top Logged
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Post by felixwillford on Dec 3, 2007 14:26:18 GMT -5
Benzalkonium chloride From Wikipedia, the free encyclopedia Jump to: navigation, search
This article may require cleanup to meet Wikipedia's quality standards.
Please improve this article if you can. (December 2007) Benzalkonium chloride Benzalkonium chloride (alkyl dimethyl benzyl ammonium chloride) is a mixture of alkylbenzyl dimethylammonium chlorides of various alkyl chain lengths. This product is a nitrogenous cationic surface-acting agent belonging to the quaternary ammonium group. It has three main categories of use; as a biocide, a cationic surfactant and phase transfer agent in the chemical industry.
Benzalkonium chloride is readily soluble in alcohol, and acetone. Dissolution in water is slow, and aqueous solutions are preferred, as they are to easier to handle. Solutions should be neutral to slightly alkaline, with colour ranging from clear to a pale yellow. Solutions foam profusely when shaken, have a bitter taste, and a faint almond-like odour which is only detectable in concentrated solutions.
Standard concentrates are manufactured as 50% and 80% w/w solutions, and sold under tradenames such as BC50, BC80, BAC50, BAC80, etc. The 50% solution is purely aqueous, while more concentrated solutions require incorporation of rheology modifiers (alcohols, polyethylene glycols, etc.) to prevent increases in viscosity or gel formation under low temperature conditions. European manufacturers range from large multinationals such as Akzo-Nobel [1]to Quatchem Ltd. [2] a privately owned UK-based enterprise, manufacturing both standard and customised benzalkonium products. Quimidroga, Brenntag, etc. are typical European distribution groups.
Applications are extremely wide ranging [3], from disinfectant formulations to microbial corrosion inhibition in the oilfield sector. It has been considered one of the safest synthetic biocides known and has a long history of efficacious use. It is currently used in human pharmaceuticals such as leave-on skin antiseptics, hygienic towelettes, and wet wipes. Alcohol-free Benzalkonium solutions are often used for skin disinfection prior to withdrawing blood for Blood Alcohol Content ("BAC") tests. Its use as a preservative in cosmetics such as eye and nasal drops attest to its general safety; however, there have been reports of allergy associated with continuous, long-term use in sensitive users, especially on mucous membranes.
The greatest biocidal activity is associated with the C12-C14 alkyl derivatives. The mechanism of bactericidal/microbicidal action is thought to be due to disruption of intermolecular interactions. This can cause dissociation of cellular membrane bilayers, which compromises cellular permeability controls and induces leakage of cellular contents. Other biomolecular complexes within the bacterial cell can also undergo dissociation. Enzymes, which finely control a plethora of respiratory and metabolic cellular activities, are particularly susceptible to deactivation. Critical intermolecular interactions and tertiary structures in such highly specific biochemical systems can be readily disrupted by cationic surfactants.
Benzalkonium chloride solutions are rapidly acting biocidal agents with a moderately long duration of action. They are active against bacteria and some viruses, fungi, and protozoa. Bacterial spores are considered to be resistant. Solutions are bacteriostatic or bactericidal according to their concentration. Gram-positive bacteria are generally more susceptible than gram-negative. Activity is not greatly affected by pH, but increases substantially at higher temperatures and prolonged exposure times.
Newer formulations using benzalkonium blended with various quaternary ammonium derivatives can be used to extend the biodcidal spectrum and enhance the efficacy of benzalkonium based disinfection products. This technique has been used to improve virucidal activity of quaternary ammonium-based formulations to healthcare infection hazards such as hepatitis, HIV, etc. Quaternary ammonium formulations are now the disinfectants of choice for hospitals. This is on account of user and patient safety even on contact with treated surfaces and the absence of harmful fumes. Benzalkonium solutions for hospital use tend to be neutral to alkaline, non-corrosive on metal surfaces, non-staining and safe to use on all washable surfaces.
The use of appropriate supporting excipients can also greatly improve efficacy and detergency, and prevent deactivation under use conditions. Formulation requires great care as Benzalkonium solutions can be readily inactivated in the presence of organic and inorganic contamination. Solutions are incompatible with soaps, and must not be mixed with anionic surfactants. Hard water salts can also reduce biocidal activity. As with any disinfectant, it is recommended that surfaces are free from visible dirt and interfering materials for maximal disinfection performance by quaternary ammonium products.
Although hazardous levels are not likely to be reached under normal use conditions, it is important to remember that benzalkonium and other detergents can pose a hazard to marine organisms. Quaternary ammonium disinfectants are effective at very low ppm levels, so it is important avoid excess in use. Responsible care ensures that we do not disrupt the fragile marine ecosystems that sustain us.
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Post by robertalouise26 on Dec 3, 2007 19:43:35 GMT -5
Dearest Kmarie thank you so very very much on that post about banzalkonium chloride. As you possibly know Grady recommended it to us. Well I have this stuff in the house all the time and so I decided to do Kyra my dog with it. What I have is only 4.5% w/v I don't know what that means. But it has helped Kyra tremendously!!! She isn't cured and will probably have to use it on her for quite awhile. I wish that I knew how frequently to apply it to her. I am soooo very pleased that it is safe and next time my arms itch I will try it and let everyone know if it has helped me. Thank you soooo much for your research Kmarie. Much love. Roberta.
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Post by felixwillford on Dec 3, 2007 21:12:20 GMT -5
I used this on my arm.......................... it killed all the morgs in that arm. I have white scars but never had anything on that particular place on my arm ever again. No itching, no biting.
I have used this in Laundry to and it does great.
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Post by Orion*** on Dec 4, 2007 3:16:25 GMT -5
Kmarie--where and how did you come by this product.... 30 years ago I used to get it in small ampuels for first aid dissinfectent--- I tried to get some a few years back and the pharmacy did not know what I was talking about-- figures--more incompatance. Sound like you were able to get it in large containers. Thanks O***
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Post by socalsandy on Dec 4, 2007 8:17:08 GMT -5
Please tell us the name so we can buy it . Thanks Sandra
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Post by grady on Dec 4, 2007 12:11:48 GMT -5
Kmarnie, check this out: A new laboratory study indicates that many antibacterial products have some value, but a product made with benzethonium chloride kills common types of non-hospital -- or "community associated" -- MRSA bacteria better than other compounds. Clinical studies to confirm the results are needed, experts say.Brand new article just published today Best Treatment Identified To Reduce Deadly Staph Infections, According To Expertwww.sciencedaily.com/releases/2007/12/071203135728.htm
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Post by grady on Dec 4, 2007 12:14:05 GMT -5
Also, KMarnie, tell us where you get it
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Post by toni on Dec 4, 2007 12:18:44 GMT -5
Here's a link on this...so moderation is key. Benzethonium is also a from of benzene. This is a component in the HIV and AIDS drugs (AZT) attacks the thymus. Your thymus responsibile for manufacturing your T4 cells. These are your killer cells responsible for attacking dangerous negative bacterium and viruses. Eventually, after so much invasion from the benzene, the production of your T4 killer cells by the thymus is seriously disrupted. This disruption, if not fixed, literally lead to AIDS (auto immune difficiency syndrome) as a result of the body no longer able to fight anything that comes it's way. poisonevercure.150m.com/benzethonium_chloride.htmAnd Grapefruit Seed extract contains this also, which I've tried it topically and internally, as many have too: www.itmonline.org/jintu/grapefruit.htm
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Post by felixwillford on Dec 4, 2007 12:23:23 GMT -5
Grady, Yes, I checked out your link, thank you: Looks like OSU is studying more than Morgellons or could Morgellons be a type of MRSA that doesn't "KILL" as quickly??? Just speculating.In laboratory studies, OSU scientists compared three types of compounds for their effectiveness in killing four strains of MRSA bacteria that are most commonly found in a public setting. The compounds were those made with neomycin and polymyxin; those made with polymyxin and gramicidin; and those made with benzethonium chloride with tea tree and white thyme oil. The first two types of products are commonly found, with slight variations, in "maximum strength" or "triple antibiotic" compounds routinely sold in drug stores. The third product is comparatively new. "Comparing these three product groups, the study showed that the benzethonium chloride product killed the community-associated MRSA bacteria more rapidly, and worked well against all four of the strains we tested," Bearden said. All of the products had some antibacterial effectiveness against MRSA bacteria, the OSU study found, but only the benzethonium chloride compound had a genuine "bactericidal" effect -- meaning it reduced the number of bacteria by a factor of 1,000 -- against all four of the tested MRSA strains. "It's worth noting that there's not a lot of data about the proven effectiveness of any of these topical, antibacterial products in preventing infections," Bearden said. "However, we know that it takes a large number of bacteria to ultimately produce an infection, and antibacterial treatments can greatly reduce their number. It's reasonable to believe that these products, which are inexpensive and easily available, have a place in protecting a nasty cut or scrape and trying to prevent a more serious infection." The OSU study was funded by Tec Laboratories of Albany, Ore., a company that sells the benzethonium chloride product From Kmarie,It appears that Tec Laboratories of Alban, Oregon sells benzethonium chloride. www.teclabsinc.com/This has product list.
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Post by felixwillford on Dec 4, 2007 12:49:05 GMT -5
Grady, Orion, Sandra, and anyone else, What I used was "alkyl dimethyl benzyl ammonium chloride" as the active ingredient. As Roberta stated................. she just found it in a cleaning product around her home. That is how it was with me. IT was June 2006 and I used it only ONCE on this area of my arm. I have NEVER had lesions like that ever again, not on my arm or anywhere since that summer. I may get maybe one or at the most two at a time on my fingers/top of hand just everyone once in a while during stress (a few times in a year)........... but no more. I took that arm to the Doctor and she said NOTHING except to order blood test which indicated INcreased White blood cells indicating infection process. I received a phone call saying....................... you don't have Lupus, but your thyroid is back to normal and I didn't need my thyroid meds anymore. SHE would not ask me how my arm was and did not want to see me again. IT was the nurse who called with the report. PM me for more info. It was an accidental discovery, as Toni states............. small and infrequent amounts are very important.
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Post by mercury on Dec 4, 2007 16:59:29 GMT -5
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Post by felixwillford on Dec 4, 2007 17:19:02 GMT -5
IT wasn't one of those, but I have used those Lysol wipes on my face and it works well.
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Post by lilsissy on Jan 3, 2010 2:24:08 GMT -5
I came across this tonight and found so much here that I wanted evryone to reread it. I have been coming across some articles that are making me think we have some strange viral cancersoccuring from particulates of some kind.
This is a letter I came across on the web, just look at what this guy has found,
Statement of Background Jungang Liang
I have been studying bacteria, viruses and other pathogens for 20 years. I graduated from the graduate school, China CDC (the previous name 'Chinese Academy of Preventive Medicine'). I was working both at Institute of Infectious Diseases (the previous name 'Institute of Epidemiology and Microbiology', one branch of China CDC) and National Vaccine & Serum Institute when I was in Beijing before 2001. These two units are the top ones for the study of Infectious disease and pathogens in China, which are responsible for the direction of the whole nation relevant work and the communication with WHO as well as other countries. I was the first one to find Genospecies I, B.burgdorferi Sensu Stricto, of B. burgdorferi Sensu lato (the pathogen of Lyme Disease) isolated in Asia (in China). In the past, people often said there was no Genospecies I of B.burgdorferi Sensu lato in Asia. I also made the first map about the Genospecies distribution of strains in China. This project conjugated with other Lyme disease epidemiological investigations received the first award of Science and Technical Progress by China government in 1993.
In 2001, I worked at Unite des Rickettsies, Faculte de Medecine,Universite de la Mediterranee (Dr. DIDIER RAOULT Lab, Marseille, France). I had found more monoclonal antibodies to Tropheryma whipplei and Mimivirus. Both pathogens were isolate strains in Dr. Didier Raoult’s Laboratory, which are responsible for Whipple’s disease and putative pneumonia agent. We successfully isolated and characterized the novel virus from the water of a cooling tower related to the outbreak of pneumonia in Bradford, England. It should be the largest known virus in the world (see the references, Science, VOL 299, 28 MARCH 2003 ).
I came to the United States in April, 2003. I worked at School of Veterinary Medicine, North Carolina State University (Dr. Edward Breitschwerdt’s Lab, Raleigh, NC) for a Post Doc project (2 years) isolating a novel canine retrovirus which was first identified in 1989. I isolated and found an unknown infection agent or agents isolated from a patient dog with severe thrombocytopenia. I proved the unknown infectious agents could be transmissible in the dogs by blood transfusion and the unknown particles exist in the nucleus of DH82 , O3O cells but not in MDCK cells. The unknown infectious agents are unique and could be recognized only by the experimental dogs, which tested and confirmed a couple times in 3 years. Besides these unknown particles, I also found the existence of anti-histone antibodies in the patients dogs. However, the results of Reverse Transcriptase (RT) assay, a crucial test for characterization of the family of Retroviruses, did not support the previous hypothesis of novel canine retrovirus despite our efforts. DH82 and O3O cell lines are made from the dogs with canine malignant histiocytosis (MH). What are these particles proliferating in DH82 and O3O cells? So far, there has no reports about it. There are three possibilities for these unknown particles: 1) The hypothesis was wrong . I, however, do not think so, at least not yet; 2) There is a wrong primer with the protocol used for the test of RT. I highly suspect it right now. 3) There is an exception to retrovirus family. I have no idea about it now.
After working at Dr. Breitschwerdt’s Lab, I was studying drug delivery (transfection of luciferase gene and its expression in Hela cells) at Chemical Department with Dr. Franzen from April, 2005 with a title of research scientist. We successfully delivered the targeting gene to the nucleus of cells by peptides. These targeting genes can alter gene expression in the host cells. We also could estimate the efficiency of the delivery. It will most greatly contribute to the treatment of cancer and heredity disease as well as the development of Pharmacology. I once tried sending gold nanoparticles but failed due to unstable mixed peptide-poly(ethylene glycol) monolayers .
My third employment in the US was in Dr. L. Jeannine Brady’s laboratory, Oral Biology, University of Florida. I came here for the study of Immunomodulation (a similar function to the adjuvant in vaccine) using isotype switch variants with the title of Biological scientist in April, 2006. I found successfully some isotype switch mutants (gene mutants) of monoclonal hybridoma cells (switching from Ig G1 to Ig G2a and Ig G2b). I did isolation of total RNA, RT-PCR and DNA sequence (not finished).
During my career in the study of microorganisms, my knowledge and technical skills have covered nearly all the fields related, including tissue culture, animal experiment, monoclonal antibodies, IFA, ELISA, SDS-PAGE , Western Blot, Immunoprecipitation, PCR and RT-PCR, gene clone and expression, sequencing, Recombinant DNA techniques, Hybridization, Bioinformatics, Data analysis, Biological Electron Microscopy, Drug delivery ,whole cell BIA core assay, et al.
Jungang Liang
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Post by lilsissy on Jan 3, 2010 2:35:20 GMT -5
this is for you skytrool factor h lyme strips factor H so we would seem to have bombay phenotype blood right? blood change universal type O was it intentional though and why? Or was it and unintended by product of another intention, I always felt that lyme bacteria assembling in chains , when they die off they would leave the polymer in the gut sacs and we could have polymer chains left behind ? Very curiors here. tinyurl.com/yjf9r8bcut, Institutes >> Zentrum der Hygiene >> Medizinische Mikrobiologie und Krankenhaushygiene >> Forschung >> Borrelien AAA Zentrum der HygieneMedizinische Mikrobiologie und KrankenhaushygieneAktuelles / VeranstaltungenKonsiliarlaboratorium BartonellaDiagnostikKrankenhaushygieneKonsiliardienstNewsletterForschungB. henselae & HIF-1BorrelienEpidemiologie und Prävention nosokomialer Infektionen Staphylococcus aureus / AntibioticsLehreMitarbeiterLiteraturverzeichnis 2008/2009Immune escape mechanism of Borrelia burgdorferi, the causative agent of Lyme disease Research Group Prof. Dr. Kraiczy, Ph.D. eMail: kraiczy(at)em.uni-frankfurt.de Tel.: +4969-6301-7165 Coworkers: Corinna Siegel, Claudia Hammerschmidt, Christa Hanssen-Hübner B. burgdorferi sensu stricto, B. afzelii, B. garinii and B. spielmanii are the causative agents of the multi-faced disorder called Lyme borreliosis, the most commonly reported vector-borne infectious disease in Germany. Spirochetes are transmitted to humans and vertebrate hosts primarily through a bite by infected Ixodes spp. ticks. For their survival in diverse environments such as arthropod vectors and vertebrate hosts, Borrelia have developed elegant and indispensable strategies to persistently infect vectors as well as diverse reservoir hosts. One particular strategy of spirochetes to efficiently overcome the innate immune system of their hosts involve natural resistance to complement-mediated killing. Our recent studies demonstrated that serum-resistant Borrelia express up to five distinct complement regulator-acquiring surface proteins or CRASPs to hijack immune regulators factor H, factor H-like protein 1 (FHL-1), and the factor H-related protein 1 (CFHR-1) from plasma for controlling complement activation on the bacterial surface and thereby escape from complement-mediated killing (Fig.). In addition, we identified and characterized on the molecular level all five CRASP proteins of serum-resistant B. burgdorferi as well as of serum-resistant B. afzelii as well as B. spielmanii, respectively.
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Post by lilsissy on Jan 14, 2010 17:38:02 GMT -5
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Post by skytroll on Jan 16, 2010 0:16:32 GMT -5
I am wondering if the mitochondria dies, than it has calcified, it is that calcification that has to be removed, what busts calcification? seems our chlorine in cells has been ionized. I think the chloride channel has been altered somehow, or the growths have blocked the chloride channel. ============= Pathology Bartter's syndrome, which is associated with renal salt wasting and hypokalemic alkalosis, is due to the defective transport of chloride ions and associated ions in the thick ascending loop of Henle. CLC-Kb has been implicated. Another inherited disease that affects the kidney organs is Dent's Disease, characterised by low molecular weight proteinuria and hypercalciuria where mutations in CLC-5 are implicated. Thomsen disease is associated with domininate mutations and Becker disease with recessive mutations in CLCN1. Cystic fibrosis is caused by a mutation in the DF508 region of the CFTR gene, which prevents the proper folding of the protein, and subsequent degradation, resulting in decreased numbers of chloride channels in the body. This causes the build up mucus in the body and chronic infections. Functions Chloride channels are important for setting cell resting membrane potential and maintaining proper cell volume. These channels conduct Cl- as well as other anions such as HCO3-, I-, SCN-, and NO3-. The structure of these channels are not like other known channels. Chloride channel subunits contain between 1 and 12 transmembrane segments. Some members of this family are activated by voltage, while others are activated by Ca2+, extracellular ligands, and pH among other modulators.[1] en.wikipedia.org/wiki/Chloride_channelI am thinking it is both voltage and ca2+ extra cell ligands. those ligands are part of this machinery. some are activated by Voltage! Some by Ca2+ extracellular ligands PH the extracellular ligands that form neoplasms are Proteoglycans. ================== will look more on that, related to heparin fibroblasts. I would be a little leary of that DCA, but, I know many must be using it. will check some... skytroll
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Post by skytroll on Jan 16, 2010 1:19:52 GMT -5
I believe Dr. H said these are involved in proteomes, of which this is "Proteoglycans are glycoproteins that are heavily glycosylated. They have a core protein with one or more covalently attached glycosaminoglycan (GAG) chain(s). The chains are long, linear carbohydrate polymers that are negatively charged under physiological conditions, due to the occurrence of sulfate and uronic acid groups. Proteoglycans occur in the connective tissue. Function Proteoglycans are a major component of the animal extracellular matrix, the "filler" substance existing between cells in an organism. Here they form large complexes, both to other proteoglycans, to hyaluronan and to fibrous matrix proteins (such as collagen). They are also involved in binding cations (such as sodium, potassium and calcium) and water, and also regulating the movement of molecules through the matrix. Evidence also shows they can affect the activity and stability of proteins and signalling molecules within the matrix. Individual functions of proteoglycans can be attributed to either the protein core or the attached GAG chain. Synthesis The protein component of proteoglycans is synthesized by ribosomes and translocated into the lumen of the rough endoplasmic reticulum. Glycosylation of the proteoglycan occurs in the Golgi apparatus in multiple enzymatic steps. First a special link tetrasaccharide is attached to a serine side chain on the core protein to serve as a primer for polysaccharide growth. Then sugars are added one at the time by glycosyl transferase. The completed proteoglycan is then exported in secretory vesicles to the extracellular matrix of the cell. Proteoglycans and disease An inability to break down proteoglycans is characteristic of a group of genetic disorders, called mucopolysaccharidoses. The inactivity of specific lysozomal enzymes that normally degrade glycosaminoglycans leads to the accumulation of proteoglycans within cells. This leads to a variety of disease symptoms, depending upon the type of proteoglycan that is not degraded. en.wikipedia.org/wiki/Proteoglycan====================== The proteoglycan is not degraded and stays and grow in tubes and forms the neoplasms of these new cancers. ========== Proteoglycans: structure, function, and role in neoplasma ====================== "Proteoglycans The majority of GAGs in the body are linked to core proteins, forming proteoglycans (also called mucopolysaccharides). The GAGs extend perpendicularly from the core in a brush-like structure. The linkage of GAGs to the protein core involves a specific trisaccharide composed of two galactose residues and a xylose residue (GAG-GalGalXyl-O-CH2-protein). The trisaccharide linker is coupled to the protein core through an O-glycosidic bond to a S residue in the protein. Some forms of keratan sulfates are linked to the protein core through an N-asparaginyl bond. The protein cores of proteoglycans are rich in S and T residues, which allows multiple GAG attachments." themedicalbiochemistrypage.org/glycans.html========================== seems related to sulphates but they mention mucopolysaccharidosis. ================== skytroll
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Post by freaky on Jan 17, 2010 1:16:39 GMT -5
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