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Jun 2, 2008 21:58:26 GMT -5
Post by kiki on Jun 2, 2008 21:58:26 GMT -5
Oh my gosh, right arfter my last post my laptop got crazy. I couldnt send any posts and every 2 min the screen filled with gibberish. When I tried to turn it off my screen went blue and wouldnt even let me turn it off. My hubby was on his annual golf trip so I couldnt use his and the desktop had to be tossed cause of the mold. I took it to be fixed but just now got it back. I lost everything on it. I cant tell you how much it worried at me that I couldnt follow-up with you guys. Im so sorry. GOOD NEWS is... still symptom free. Also, for the first time in 4 yrs I had a cold! But my best news is the results of some tests I had done mos ago. A MRI or CT scan(dont remember which- have had both) showed granulomas in my lungs. My hero Dr asked if Id be willing to let lab try to extract one. She knew full well I would have endured a heck of alot more than that if there was even a remote possibility for answers. So down my throat went the tube. And wow was it worth it. The granulomas had larvae in them!!! Then she had them stick a swab up my nose farther than I thought possible. Again- SO worth it. Same larvae sacs found. That must have given her a thought cause then she had my gyno check out my other "mucus membrane". Bingo. Im having a CT scan Wed so it will be interesting to see those results. The Noxafil is obscenely expensive. 3 bottles cost $1800.00 (less than a months worth!) BUT ins pd all but $60.00. My Dr put myco?something- (whatever the name for fungi infection is) AND morgellons!! She warned me it could hurt chance of ins paying but (dont laugh pls), I felt since I was fortunate enough to have such good Drs I was morally responsible to use it for the greater good. BCBS never questioned it. Again, Im sorry I couldnt let you know sooner.
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Jun 2, 2008 22:33:19 GMT -5
Post by godsgrace on Jun 2, 2008 22:33:19 GMT -5
vivi..... Please read my posts regarding mycoplasma. Practically everyone alive is infected with it. it is found in insects...mosquitos, ticks, fleas, mites ect...so people contract it through bug bites. It is also found in milk and meat....I have a feeling that's why so many people are vegans/vegetairans. It is also spread through aerosol spraying...chemtrails. There are several species of it and the most harmful ones were manipulated on Plum Island in a lab. In 1957, millions of mosquitos were bred in Canada and injected wityh mycoplasma at Queen's University, Canada. The mosquitos were then let go in Punta Gorda Fl and over a period of a few weeks, 350 people came down with Myalgic Encephalomyelitis...what we here in the US call Chronic Fatigue Syndrome. I know alot about mycoplasma. When I was diagnosed the doctor told me that they don't know what causes CFS. Not a good enough answer for me so I went searching. I found info all over the web indicating that mycoplasma is responsible for most of the illness we know of today, if not all of it. Glad you are well.... godsgrace the whole story here....Donald Scott..one of my hero's!! tinyurl.com/9z67s
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Jun 2, 2008 22:44:00 GMT -5
Post by zabrubon on Jun 2, 2008 22:44:00 GMT -5
Wow, Vivi, that is great. Symptom free. How did you find this doctor. Is she an internist? Can i pm you for the name? I am doing ok, but my face is a mess. Have lots of energy but skins a total mess. Congratulation again. I can't believe the price of the medicine. Holly cow. Howlong did you take it? ChicagoBonnie
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Jun 2, 2008 22:49:13 GMT -5
Post by zabrubon on Jun 2, 2008 22:49:13 GMT -5
Noxafil
Generic Name: posaconazole Dosage Form: oral suspension
PRODUCT INFORMATION
Noxafil Description Noxafil® (posaconazole) is a triazole antifungal agent available as a suspension for oral administration.
Posaconazole is designated chemically as 4 - [4 - [4 - [4 - [[(3R,5R) - 5 - (2,4 - difluorophenyl)tetrahydro - 5 - (1H - 1,2,4 - triazol - 1 - ylmethyl) - 3 - furanyl]methoxy]phenyl] - 1 - piperazinyl]phenyl] - 2 - [(1S,2S) - 1 - ethyl - 2 - hydroxypropyl] - 2,4 - dihydro - 3H - 1,2,4 - triazol - 3 - one with an empirical formula of C37H42F2N8O4 and a molecular weight of 700.8. The structural formula is:
Posaconazole is a white powder and is insoluble in water.
Noxafil® Oral Suspension is a white, cherry-flavored immediate-release suspension containing 40 mg of posaconazole per mL and the following inactive ingredients: polysorbate 80, simethicone, sodium benzoate, sodium citrate dihydrate, citric acid monohydrate, glycerin, xanthan gum, liquid glucose, titanium dioxide, artificial cherry flavor, and purified water.
Noxafil - Clinical Pharmacology
Pharmacokinetics
Absorption Posaconazole is absorbed with a median Tmax of ~3 to 5 hours. Dose proportional increases in plasma exposure (AUC) to posaconazole were observed following single oral doses from 50 mg to 800 mg and following multiple-dose administration from 50 mg BID to 400 mg BID. No further increases in exposure were observed when the dose was increased from 400 mg BID to 600 mg BID in febrile neutropenic patients or those with refractory invasive fungal infections. Steady-state plasma concentrations are attained at 7 to 10 days following multiple-dose administration.
Following single-dose administration of 200 mg, the mean AUC and Cmax of posaconazole are approximately 3 times higher when administered with a nonfat meal and approximately 4 times higher when administered with a high-fat meal (~50 gm fat) relative to the fasted state. Following single-dose administration of 400 mg, the mean AUC and Cmax of posaconazole are approximately 3 times higher when administered with a liquid nutritional supplement (14 gm fat) relative to the fasted state (see TABLE 1). In order to assure attainment of adequate plasma concentrations, it is recommended to administer posaconazole with food or a nutritional supplement. (See DOSAGE AND ADMINISTRATION.)
TABLE 1: The Mean (%CV) [min-max] Posaconazole Pharmacokinetic Parameters Following Single-Dose Suspension Administration of 200 mg and 400 mg Under Fed and Fasted Conditions Dose (mg) Cmax (ng/mL) Tmax* (hr) AUC(I) (ng∙hr/mL) CL/F (L/hr) t1/2 (hr) * Median [min–max] † n=15 for AUC(I), CL/F and t1/2 ‡ The subject with Tmax of 36 hrs had relatively constant plasma levels over 36 hrs (1.7 ng/mL difference between 4 hrs and 36 hrs) § n=10 for AUC(I), CL/F and t1/2 200 mg fasted (n=20)† 132 (50) [45–267] 3.50 [1.5–36‡] 4179 (31) [2705–7269] 51 (25) [28–74] 23.5 (25) [15.3–33.7] 200 mg nonfat (n=20)† 378 (43) [131–834] 4 [3–5] 10,753 (35) [4579–17,092] 21 (39) [12–44] 22.2 (18) [17.4–28.7] 200 mg high fat (54 gm fat) (n=20)† 512 (34) [241–1016] 5 [4–5] 15,059 (26) [10,341–24,476] 14 (24) [8.2–19] 23.0 (19) [17.2–33.4] 400 mg fasted (n=23)§ 121 (75) [27–366] 4 [2–12] 5258 (48) [2834–9567] 91 (40) [42–141] 27.3 (26) [16.8–38.9] 400 mg with liquid nutritional supplement (14 gm fat)(n=23)§ 355 (43) [145–720] 5 [4–8] 11,295 (40) [3865–20,592] 43 (56) [19–103] 26.0 (19) [18.2–35.0]
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Jun 2, 2008 23:13:47 GMT -5
Post by freyman on Jun 2, 2008 23:13:47 GMT -5
vivi..... Please read my posts regarding mycoplasma. Practically everyone alive is infected with it. it is found in insects...mosquitos, ticks, fleas, mites ect...so people contract it through bug bites. It is also found in milk and meat....I have a feeling that's why so many people are vegans/vegetairans. It is also spread through aerosol spraying...chemtrails. There are several species of it and the most harmful ones were manipulated on Plum Island in a lab. In 1957, millions of mosquitos were bred in Canada and injected wityh mycoplasma at Queen's University, Canada. The mosquitos were then let go in Punta Gorda Fl and over a period of a few weeks, 350 people came down with Myalgic Encephalomyelitis...what we here in the US call Chronic Fatigue Syndrome. I know alot about mycoplasma. When I was diagnosed the doctor told me that they don't know what causes CFS. Not a good enough answer for me so I went searching. I found info all over the web indicating that mycoplasma is responsible for most of the illness we know of today, if not all of it. Glad you are well.... godsgrace the whole story here....Donald Scott..one of my hero's!! tinyurl.com/9z67sGodsgrace, I agree with you that mycoplasmas are a key component in morgellons as well as many other diseases and I too have researched them significantly. For about a year I persued the bryozoan as a component in morgellons and found strong ties between it and the mycoplasmas, like this abstract www.springerlink.com/content/r67146683v424378/I still believe there are characteristics of morgellons that can only be explained by the bryozoan but there is one extremely important characteristic that can only be explained by the sponge, this characteristic is even documented by Cliff Mickelson in his findings where he describes how this organism can break apart and come back together and how it travels like a liquid, this can only be explained by the characteristic of cell disassociation/ reaggregation and is only known to occur in sponges. I take the position that one day science will place both of these organisms in the same class because they are so extremely similar to each other. It was very hard for me to drop the bryozoan as my target but as much as I tried I simply could not find evidence to suggest that the bryozoan possessed this trait. I think you may find it worthwhile to research the connection between the mycoplasma and the sponge and/or the bryozoan because by itself the mycoplasma cannot explain the fibers.
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Post by Sidney on Jun 3, 2008 1:01:03 GMT -5
Vivi, will you please share with us the species of Larva found in your lungs and nasal passages?
I'm sure everyone is as curious as I am.
Were you treated for parasites as well as fungal infection?
If so, please let us know the meds prescribed.
Congratulations and good luck.
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Post by godsgrace on Jun 3, 2008 8:37:13 GMT -5
Steve, since my entry into this forum, I have been blasting MYCOPLASMA information everywhere. I'm sure some are tired of hearing about it. when researching my illness, I found a symtom on the list that I didn't have but my sister does. Erythema Nodosum. At that point I called her and asked her if she had anymore symptoms from the list. Turns out she had several. I then called every family member and asked them. They too had several of the symptoms. The interesting part comes next. I called my sister in law, her sister and their mother and all 3 of them had many of the symptoms as well (some severe) That's when I started seeing the dots. When I found the Nexus article by Don Scott, it hit me. EVERYONE has it! EVERYONE. To different degres. My wish is that people here in this forum will have PCR testing done for all of the species of mycoplasma infection. It would prove my hypothesis. I myself am working up the nerve to ask my doctor. He is US Military trained so that might be my biggest challenge yet. I am still searching for the myco connection as I know it is there, somewhere. I don't believe that mycoplasma is the CAUSE of Morgellons but I somehow feel it may be a catalyst. Thanks Steve!!!!!!!! godsgrace
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Post by toni on Jun 3, 2008 9:17:06 GMT -5
Vivi, this is such great news! I'm so happy you're feeling better! and so glad your docs have stayed with you, and finally found culprits! Larvae! Wow...that's what I believe has been tickling in my lesion too that I pick out daily. Does you doc have any idea "how fibers are being sucked into the skin", and what kind of parasites would pull them in, if that's the case? Is there any way your doc will or can take a pic, and allow you to have that of the "larvae" for you to share? And just as Sid said, we're holding our breath hoping they can identify what kind of larvae they've found. Such great news! ;D This is a link of pics of the parasite I've gotten out of my lesion and daily, larvae galore! lymebusters.proboards39.com/index.cgi?board=rash&action=display&thread=9545&page=1I guess it was last year, maybe 06, Dr. K told me there seemed to be 3 different parasites involved also.
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Jun 3, 2008 14:00:03 GMT -5
Post by westside on Jun 3, 2008 14:00:03 GMT -5
Dear Vivi I already added to your "cornfield" thread. I am so happy you found the doctors you did. EVERYONE!: i think Vivi's news is perhaps the most important we will ever read. I do believe her Doctor has cracked this case. Why are all of the other Doctors across the country failing to detect this....not even testing us....jumping to the DOP diagnosis. I did a search to pull up Vivi's last 50 posts(just click on her name in yellow on any of the threads she's started and fill in the "search last.... posts" funtion)You can read the posts from feb. when Vivi's friend posted about her being in the hospital. This is so important. Bless her wonderful doctor!!!!!!
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Jun 3, 2008 14:54:17 GMT -5
Post by skytroll on Jun 3, 2008 14:54:17 GMT -5
Mycotoxin vs mycoplasma Greek μύκης (mykes, mukos) "fungus") is a toxin produced by an organism of the fungus kingdom, which includes mushrooms, molds and yeasts. Most fungi are aerobic (use oxygen). Fungi are found almost everywhere in extremely small quantities because of their spores, and are most commonly microscopically small. They consume organic matter, wherever humidity and temperature are sufficient. Where conditions are right, fungi proliferate into colonies and mycotoxin levels become high. Toxins vary greatly in their severity. Some fungi produce severe toxins only at specific levels of moisture, temperature or oxygen in the air. Some toxins are lethal, some cause identifiable diseases or health problems, some weaken the immune system without producing symptoms specific to that toxin, some act as allergens or irritants, and some have no known effect on humans. Some mycotoxins generally have more negative impacts on farm animal populations than on humans. Some mycotoxins are harmful to other micro-organisms such as other fungi or even bacteria; penicillin is one example. Mycotoxins can appear in the food chain as a result of fungal infection of crops, either by being eaten directly by humans, or by being used as livestock feed. Mycotoxins greatly resist decomposition or being broken down in digestion, so they remain in the food chain in meat and dairy products. Even temperature treatments, such as cooking and freezing, do not destroy mycotoxins. Buildings are another source of mycotoxins. Public concern over mycotoxins increased following multi-million dollar toxic mold settlements in the 1990s. The negative health effects of mycotoxins are a function of the concentration, the duration of exposure and the subject's sensitivities. The concentrations experienced in a normal home, office or school are often too low to trigger a health response in occupants. en.wikipedia.org/wiki/Mycotoxinsmycoplasmas: Mycoplasmas are spherical to filamentous cells with no cell walls. There is an attachment organelle at the tip of filamentous M pneumoniae, M genitalium, and several other pathogenic mycoplasmas. Fried-egg-shaped colonies are seen on agar. The mycoplasmas presumably evolved by degenerative evolution from Gram-positive bacteria and are phylogenetically most closely related to some clostridia. Mycoplasmas are the smallest self-replicating organisms with the smallest genomes (a total of about 500 to 1000 genes); they are low in guanine and cytosine. Mycoplasmas are nutritionally very exacting. Many require cholesterol, a unique property among prokaryotes. Ureaplasmas require urea for growth, another unusual property. Mycoplasmas have surface antigens such as membrane proteins, lipoproteins, glycolipids, and lipoglycans. Some of the membrane proteins undergo spontaneous antigenic variation. Antibodies to surface antigens inhibit growth; various serological tests have been developed and are useful in classification. gsbs.utmb.edu/microbook/ch037.htmVIVI, glad to hear some real docs are still out there. Hope you continue to heal. skytroll
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Jun 3, 2008 15:54:29 GMT -5
Post by Sidney on Jun 3, 2008 15:54:29 GMT -5
I'm happy to learn of your healing, Vivi. But, the questions remain unanswered at this point.
What kind of larvae were found and identified?
Did they go to a local lab? Who identified the Larvae?
An event of this nature isn't run of the mill. This is the sort of thing written up and published in a medical journal.
Is someone going to do that?
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Jun 3, 2008 17:41:08 GMT -5
Post by westside on Jun 3, 2008 17:41:08 GMT -5
Sidney My thought on your post is that this would not be published in a medical journal as a new and novel because it is probably "run of the mill" and quite a common thing in places like India,South America and the like. Just not common or obvious to U.S. MDs. It should be published... the fact that it is occurring in the U.S.(if in fact this is "it"). And...it may be happening here now because of the genetic modificatons being made to the seeds,crops, or the weird concoctions they are creating as pesticides or water clean-up things??? I'm filled with the kind of hope i have not felt in a long time. I don't know how you have endured this disease as long as you have Syd! You are a very strong woman! It has only been 4 years for me and i really don't know how much longer i can endure it.
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Jun 3, 2008 23:25:55 GMT -5
Post by godsgrace on Jun 3, 2008 23:25:55 GMT -5
Steve, Sky.. By Mycoplasma, I mean the ones that have been manipulated by Merck researchers hired by the US gov't for bioweapons research.... not the mycoplasma originally found in nature. Mycoplasmas are paving the way for everthing else to take up in our bodies and make a home....even Morgellon's IMO www.whale.to/m/scott7.htmlgg
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Post by Jill on Jun 4, 2008 6:57:49 GMT -5
Vivi,
Glad you were able to find a doctor that would help you! Are the Granuloma larvae analyzed yet? Please let us know what was discovered?
Godsgrace, No doubt in my mind that MFI set the stage for all that followed.
Jill
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Post by godsgrace on Jun 4, 2008 7:54:59 GMT -5
Jill, you and I are on the same page!!!
MFI...mycoplasma fungal infection? just guessing...never saw it written that way.
Steve Frey says he thinks myco is involved too!
I just know it.....somehow.
bless
gg
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Post by janedough on Jun 4, 2008 8:27:39 GMT -5
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Post by toni on Jun 4, 2008 8:59:25 GMT -5
I agree, he really has Janedough! If you have Tam Tam's link handy, would you post it please? Thank you.
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Jun 4, 2008 12:54:00 GMT -5
Post by janedough on Jun 4, 2008 12:54:00 GMT -5
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Jun 4, 2008 13:28:56 GMT -5
Post by toni on Jun 4, 2008 13:28:56 GMT -5
Janedough, Thank you thank you! I'm putting it where I won't misplace it again.
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Jun 4, 2008 13:34:30 GMT -5
Post by skytroll on Jun 4, 2008 13:34:30 GMT -5
Thanks Janedough, that is part of the chlorophyll combination, as he talks of. The sponges and this s. cerevisiae yeast, fungal is mycotoxin. This link talks of the Chlamydomonas eugametos this was an acid treatment plan? Chlamydomonas eugametos www.pubmedcentral.nih.gov/articlerender.fcgi?artid=285648used in polypeptides: enzymes? Immuno-electron microscopic quantification of the fucoxanthin chlorophyll a/c binding polypeptides Fcp2, Fcp4, and Fcp6 of Cyclotella cryptica grown under low- and high-light intensities Frank Becker; Erhard Rhiel Geomicrobiology, ICBM, University of Oldenburg, Germany Corresponding author SUMMARY The diatom Cyclotella cryptica was grown under low- and high-intensity white light of 50 and 500 µmol photons m–2 s–1, respectively. Western immunoblotting showed that the diatom adapted its light-harvesting apparatus, giving rise to different amounts of distinct fucoxanthin chlorophyll a/c binding polypeptides (Fcp). The amount of Fcp2 was approximately two-fold higher under low-light than under high-light conditions, whereas the amount of Fcp6 increased four- to five-fold under high-light conditions. For Fcp4, no significant differences were detected in response to either light regime. Cells of Cyclotella grown under high- and low-light intensity were subjected to immunoelectron microscopy. Quantification of the gold label, expressed as gold particles per µm2, confirmed the results obtained by Western immunoblotting. Exposure to low light resulted in the detection of approximately six times more Fcp2-bound gold particles per µm2 in thylakoid membranes, whereas in cells grown under high light the number of Fcp6-bound gold particles increased ten-fold. For Fcp4, similar amounts of gold particles per µm2 were counted under the two light regimes. These immunocytochemical results confirmed molecular data derived from phylogenetic analyses of the sequences of genes encoding fucoxanthin chlorophyll a/c binding polypeptides (fcp genes) and from measurements of steady-state fcp mRNA concentrations. The results show that Fcp2 and Fcp6 accumulate under low- and high-light intensity, respectively, whereas Fcp4 seems to be constitutively synthesized. [Int Microbiol 2006; 9(1):29-36]. Key words: Cyclotella · Bacillariophyceae · photosynthesis · light-harvesting complexes · immunogold-labeling electron microscopy Toxicology studies on: pesticides www.pesticideinfo.org/List_AquireAll.jsp?Species=1472don't know if this is pertinent or not? palmelloids The green alga Chlamydomonas reinhardtii usually occurs in cultures as single, biflagellated cells. However, C. reinhardtii is known for its ability to form gelatinous and palmelloid stages that arise as a result of an interaction with its environment. Exponentially growing unicellular C. reinhardtii formed palmelloid colonies rapidly within 25 h when cultured together with their enemy the rotifer Brachionus calyciflorus. Consequences of palmelloid formation for population dynamics of both C. reinhardtii and B. calyciflorus were examined in continuous flow systems. Palmelloids were only formed in a one-stage system where B. calyciflorus grazers and C. reinhardtii prey were cultured together, but not in a two-stage system in which mainly unicellular C. reinhardtii was pumped into a rotifer culture placed in darkness. The rotifer abundance was lower and the algal biomass higher in the one-stage system compared to the grazing unit of the two-stage system. Inasmuch as palmelloids seemed to give C. reinhardtii cells resistance to grazing, we suggest that at least one of the reasons why C. reinhardtii is capable of forming palmelloids is to cope with herbivory. talks of the rotifers again cat.inist.fr/?aModele=afficheN&cpsidt=17892213If we take tam tams work, Steve Frey's and Dr. H. we may get there. Skytroll
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