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Post by skytroll on Aug 9, 2008 9:16:02 GMT -5
Seems TM4 and TM7 are bacteriphages that attack certain, bacterias. acidobacteria Gammaproteobaceria Deltaproteobacteria Then how did the bacteriphages get there? maybe nitrate transporters? www.genetics.org/cgi/content/full/169/3/1369?ck=nckmmmmmmm seems there is TM1 - TM12.... or more? skytroll
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Post by stevefrey on Aug 9, 2008 17:14:35 GMT -5
Thanks to Jeff and his thread "fibers granulomas" I have uncovered a critical piece of evidence linking trichoplax adhaerens to "Granulomas" which are seen in a variety of diseases such as Crohn's disease, tuberculosis, leprosy, sarcoidosis, berylliosis and syphilis, Wegener's granulomatosis and Churg-Strauss syndrome. Many types of granulomas contain inclusions known as "asteroid bodies" pathhsw5m54.ucsf.edu/case32/image323.htmlwww.ncbi.nlm.nih.gov/pubmed/11274065Trichoplax adhaerens is comprised of four types of cells one of which is known as a "fiber cell". www.ucmp.berkeley.edu/phyla/placozoa/placozoa.htmlI am very early into researching this aspect and I'm certain there will be much more evidence to follow.
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Post by chamberlin on Aug 16, 2008 10:02:17 GMT -5
Steve ...this research is getting pretty exciting, not that i understand it....but the idea of it connecting to the big mystery and a big unravelling of that mystery....is my solid prayer. Keep up the good work!
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Post by stevefrey on Aug 23, 2008 19:01:17 GMT -5
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Post by stevefrey on Aug 24, 2008 4:39:48 GMT -5
I'm going to post another article that adresses the so called "associated" organisms of the sponge because after all this is the key to it all. Science comes across like they know whats going on with their "Commensal relationships are common between sessile plants or animals" routine but if you'll notice at the end of the article they sing a different song. The fact of the matter is they really know nothing about whats going on with the so called "associated" organisms. How in the world can you explain away a number like 17,000, thats how many "associated" organisms that were found in a single sponge colony. My claim that these organisms are not "associated" with the sponge but instead are "products" of the sponge may sound radical but if you really think about it, it's the only logical explanation, and once you've accepted this idea everything comes together. oceanexplorer.noaa.gov/explorations/02sab/logs/jul28/jul28.html
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Post by stevefrey on Aug 26, 2008 0:14:17 GMT -5
Here is another intersting article on Trichoplax adhaerens adressing it's highly unusual mitochondrial genome. As you can see by the comment in pink Science sees this genome as evidence of evolution whereas I see it as evidence of "alternate gene storage" (my term) and the source of the alternate genes was from vertebrates, particularly humans. Can Science honestly believe that Trichoplax has all of these unused genes belonging to vertebrates because of evolution, it doesn't make any sense, there has to be another reason, and in the greater scheme of things the evidence suggests that there is, Trichoplax adhaerens possesses all of these genes because of their ability to copy the genomes of other organisms, possibly through contact alone, not unlike bacteria. I contend that the sponge, atleast one class, also possesses this ability. Makes a lot more sense than what is currently accepted. arstechnica.com/journals/science.ars
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Post by stevefrey on Aug 26, 2008 1:55:19 GMT -5
Here is just one example of just how adaptable the sponge is. This change is dramatic to say the least, it would be on the order of replacing our lungs with gills, but as you can see the sponge appears to have the ability to do whatever is necessary to survive. Notice the "filaments", if we could only get a sample. www.thefreelibrary.com/Deep-sea+sponge+reaches+out,+devours-a016623373
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Post by stevefrey on Aug 26, 2008 3:13:43 GMT -5
Here is more on the carnivorous sponge. What other organism on the planet can do this.
If I understand this correctly, the sponge dis-associates itself and each cell moves independantly towards the prey. Sounds like sponge cells can do pretty well on their own, as single celled organisms, what a mess.
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Post by ANTHILL on Aug 27, 2008 9:57:10 GMT -5
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Post by stevefrey on Sept 3, 2008 2:02:59 GMT -5
As I have stated on an occasion or two, it is my contention that atleast some species of porifera and placozoa possess the ability to both mimic as well as replicate other organisms. A key component of this theory is that the replica is "imperfect", thus the creation of a new species. Additionally, the suspected replicas in many cases will exhibit traits and characteristics not shared with other orgainsms in it's phylum. Agrobacterium is a good example, this bacteria possesses a unique trait and coincidently it has been isolated from a sponge, in a relationship that is more than just casual, examples like this are numerous.
I would now like to draw attention to another group of organisms that fall into this "unusual" catagory. The group of Fungi formally classied in the phylum Deuteromycota which is no longer recognized as a taxon. These Fungi are commonly referred to as "imperfect" fungi because they exhibit characteristics unlike the other fungi phylums, and a point worth mentioning
they have never been observed undergoing sexual reproduction
and they have no cell walls.
Pennicilum is an example of a deuteromycete. Athlete's foot is caused by a deuteromycete.
and as in so many other cases, deuteromycetes have been isolated from sponges.
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Post by stevefrey on Feb 27, 2009 7:20:17 GMT -5
Guess what, I'm back!
And yes I'm still following the same path, do I even need to remind anyone? It's the sponge damnit!
While seeking a connection between the sponge and poly-γ-glutamates, which are the source of the stinging cells in jellyfish, I came across a most interesting study that provides solid support to my theory.
The article is titled Supplemental data: Horizontal gene transfer and the evolution of cnidarian stinging cells
Here is a quote from that article;
BLAST searches with sequences of the three genes essential for PGA synthesis in bacteria (the “pgs” genes AA, B, C) identified transcripts showing high similarity with pgsAA in four cnidarian species, two anthozoans and two hydrozoans. Aligned with pgsAA amino-acid sequences from Bacteria, these cnidarian sequences showed a high similarity of the primary structure over more than 170 residues, clearly excluding convergence.
This prompted us to search for pgsAA in all available complete genomes from Bacteria, Archaea and Eukaryota.
Among metazoan genomes, in addition to cnidarian species, pgsAA sequences were detected in the sponge Amphimedon queenslandica, in the plant-parasitic nematode genera Meloidogyne and Heterodera, in the annelid Capitella sp. and in Aedes aegyptii. They were absent from all other investigated bilaterian genomes.
In non metazoan eukaryotes, pgsAA sequences were present only in the choanoflagellate Monosiga brevicollis, in some ascomycete belonging to the Trichocomaceae, in the ascomycete Trichoderma, and in the green algae Ostreococcus lucimarinus.
Now I would like to explain just why the few sentences above are so relevant to my theory that the sponge is the ultimate origin of the really big picture and how it has and still does manipulate every form of life on this planet, it is the ultimate enemy.
While I am still uncertain as to the exact relationship between the sponge and the Cnidarians(jellyfish) the fossil evidence dictates that the sponge was here first so I believe that based on this fact the sponge is the origin.
It is important to understand the term Metazoan, it simply means multicellular animals, in lieu of single celled organisms. So if we look at this the way most of Science thinks that life on this planet evolved we would start with the single celled organisms.
Enter the choanoflagellate, as described in the quote from the article, one of only three single celled organisms that possess the genes responsible for the stinging cells in jellyfish.
Now let me give you the most basic, all encompassing description, of a sponge. Don't visualize an organism that most of Science portrays in the vast majority of the literature as being a colony of tube shaped animals pumping water in and out of a cavity because this simply does not do justice to what this organism actually is. It can and usually does take the form of a tube in order to form a cavity in which it can pump water in and out of in order to collect food but it takes this form through the use of it's interior skeleton of spicules but that doesn't mean it has to, nor does it have to feed in such a manner.
First of all, a sponge is a collection of five different types of cells that are loosely, and I emphasize loosely because this is extremely important, held together forming a multi celled animal with no defined shape or form, it can only be defined as a blob. No organs, no brain, no respiratory system, no nervous system, no top, no bottom, no left, no right, and most importantly no tissues that in all other multi celled organism is what holds the cells together, this is one of the major factors setting this organism apart from all others, I cannot over emphasize this fact.
Secondly, about these five different types of cells that comprise a sponge, well any one of them can turn into any of the other four at any time it wants to, so what does that tell you, they're basically all the same right? And of these five different versions of the same thing (cell) one of them is identical, and again I cannot over emphasize this fact, identical to the choanoflagellate which is why Science theorizes that the sponge evolved from the choanoflagellate.
Third, and this is the big one, this collection of loosely held together cells that comprise what science classifies as the multi celled organism the sponge can literally disassemble itself into individual single cells that can act on their own, move and attack prey own their own, survive on their own and then recollect and reassemble back into the loosely held collection of cells that make it a sponge, and would you believe that each cell actually goes back into the same position in the collection that it was in prior to disassembly!
In conclusion, based on these facts I don't think the sponge should be considered a multi celled organism at all, in reality it is actually an army of cells that collect together for a purpose not a need and these calls are ultimately individual choanoflagellates
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Post by stevefrey on Mar 4, 2009 5:58:12 GMT -5
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Post by stevefrey on Mar 4, 2009 6:46:59 GMT -5
Analysis of the draft gene set reveals that M. brevicollis possesses protein domains characteristic of metazoan Notch and Hedgehog (Hh) proteins, some of which were previously thought to be unique to metazoans. The presence of these domains in disparate peptides in M. brevicollis suggests that domain shuffling has occurred in these proteins since the separation of the choanoflagellate and metazoan lineages.
[/color] www.nature.com/nature/journal/v451/n7180/full/nature06617.html
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Post by violet on Mar 4, 2009 12:26:27 GMT -5
This is a fascinating article, Steve. I saw on T.V. awhile back how sponges are used in experiments a lot. I think your theory sounds very valid that sponges are a part of, or the reason for, Morgellons. So many theories sound valid, though, and it's hard to know for sure just which is correct and which is not (or if all have some component to Morgellons). Thanks for sharing the article. Have you contacted Wymore, Citovsky, or any of the other known researchers of Morgellons with your thoughts?
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Post by stevefrey on Mar 18, 2009 7:15:03 GMT -5
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Post by stevefrey on Mar 18, 2009 21:07:27 GMT -5
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Post by stevefrey on Mar 20, 2009 21:05:35 GMT -5
Lately I've been venturing into territory that is currently way over my head, DNA and genomes, and today I came across something that I think may be a key element in all of this. While reading this article Glass Sponges and Bilaterian Animals Share Derived Mitochondrial Genomic Features: A Common Ancestry or Parallel Evolution?mbe.oxfordjournals.org/cgi/content/full/24/7/1518#FIG1I discovered that glass sponges use a modified genetic code for two of the 20 standard amino acids, tryptophan and serine, and apparently this is highly unusual. Well these two amino acids play important roles in humans and what I find interesting is how closely related these roles are to the symptoms of morgellons. These are the symptoms from a lack of tryptophan: Depression Anxiety Irritability Impatience Impulsiveness Inability to concentrate Weight gain or unexplained weight loss Slow growth in children Overeating and/or carbohydrate cravings Poor dream recall Insomnia and Serine is especially important to proper functioning of the brain and central nervous system. I think this warrants further research
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Post by lilsissy on Mar 20, 2009 22:52:33 GMT -5
FAVUS
noticed that before,
and I remember this......
In the summer and fall of 1989, hundreds of people taking tryptophan supplements in the U.S. began to report the development of serious side effects including muscle and joint pain, high fever, weakness, swelling of the arms and legs, and shortness of breath, a constellation of symptoms that later became known as eosiniphilia-myalgia syndrome (EMS).
Upon investigation, it was discovered that nearly all of the cases of EMS could be traced back to a contaminant found in one batch of tryptophan produced by a Japanese manufacturer called Showa Denko K.K.
While all manufacturers of supplemental tryptophan synthesized this amino acid through a fementation process using bacteria, several months before the outbreak of EMS, Showa Denko K.K. had altered its process to make it more efficient and was apparently unaware that a toxic contaminant was being produced.
The United States Food and Drug Administration took immediate steps to limit the availability of tryptophan, and since 1989 this amino acid has not been sold as a dietary supplement. Tryptophan is still available, however, for use in the manufacture of infant formulas and entereral and parenteral (intravenous) nutritional supplements prescribed by physicians.
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Post by Carrie♥ on Mar 21, 2009 20:17:27 GMT -5
Hey FrenchFried Man...you've got some questions to answer bro! Hi Steve, I think that your research and knowledge of the sponge is to be applauded and it is definitely a morgellons theory worth pursuing and should be pursued by the science community along with several other theories. I am curious about the following and I asked you about some of these questions previously on YouTube: How do you think we humans became infected with the sponge?
Why are there dense pockets of victims in Texas, California and Florida?
Is it contagious?
If not, why do our pets become infected or how do our pets become infected, including birds, snakes, turtles (pets that do not usually sleep with their masters)?How would the sponge make bio-hazard signs, flower and heart shapes on the human body? Do you still think that copper might help cure or at least knock down the disease? And if so, why? Why does our hair hollow out and move around like a Medusa? I am really impressed with what you have accomplished. And I wish that I had one ounce of your intelligence and tenacity and I really like the way that you compose your posts. I hope that you are right. Abbie I wonder how our dear Abbie is anyway. I wonder how a free living Sponge can live as a parasitic creature...hum !?! Simple answers please...we're not all genius's like you ;D! And what is the big parasite that we all feel? And why are our fibers yet identifiable if it's this well studied sponge?
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Post by Carrie♥ on Mar 21, 2009 20:20:38 GMT -5
Ah ha! That was one of my favoritest episodes Ant! Are you sponge worthy Daryl? Ah yeah...you betcha !
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